Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors (Q31814812)

4 July 2017

title

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors (English)

1 reference

MYCN proto-oncogene, bHLH transcription factor

4 July 2017

main subject

1 reference

GOA release 2020-03-11

kinase binding

1 reference

GOA release 2020-03-11

Mark W Richards

1

0 references

Selena G Burgess

Selena G Burgess

2

0 references

Louis Chesler

Louis Chesler

6

0 references

Richard Bayliss

Richard Bayliss

7

0 references

Evon Poon

Evon Poon

3

0 references

author name string

Anne Carstensen

4

1 reference

4 July 2017

Martin Eilers

5

1 reference

4 July 2017

language of work or name

English

0 references

publication date

11 November 2016

1 reference

full work available at URL

4 July 2017

number of pages

6

1 reference

based on heuristic

inferred from page(s)

http://eprints.whiterose.ac.uk/105919

content deliverer

White Rose Research Online

object of statement has role

postprint

1 reference

White Rose Research Online

http://eprints.whiterose.ac.uk/105919

Proceedings of the National Academy of Sciences of the United States of America

15 December 2018

published in

1 reference

4 July 2017

volume

113

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4 July 2017

issue

48

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4 July 2017

page(s)

13726-13731

1 reference

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain

4 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

MYC: connecting selective transcriptional control to global RNA production.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

The structure of C290A:C393A Aurora A provides structural insights into kinase regulation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Taming of the beast: shaping Myc-dependent amplification

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Drugging MYCN through an allosteric transition in Aurora kinase A

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Myc and its interactors take shape.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Emerging landscape of oncogenic signatures across human cancers

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

14 July 2018

Decision making in xia2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

14 July 2018

Cancer genome landscapes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Myc proteins as therapeutic targets

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

MolProbity: all-atom structure validation for macromolecular crystallography

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Phasercrystallographic software

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Modelling Myc inhibition as a cancer therapy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Transcriptional regulation and transformation by Myc proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Coot: model-building tools for molecular graphics

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

PHENIX: building new software for automated crystallographic structure determination

14 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

14 July 2018

https://api.crossref.org/works/10.1073%2FPNAS.1610626113

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137718

Transposition and amplification of oncogene-related sequences in human neuroblastomas

14 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610626113

Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610626113

N and C-terminal sub-regions in the c-Myc transactivation region and their joint role in creating versatility in folding and binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610626113

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610626113

21 January 2018

Identifiers

DOI

10.1073/PNAS.1610626113

1 reference

Dimensions Publication ID

4 July 2017

Altmetric DOI

10.1073/PNAS.1610626113

0 references

CORE ID

153790907

0 references

0 references

1 reference

4 July 2017

1 reference