Fas cell surface death receptor (Q1649375)

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mammalian protein found in Homo sapiens

• Fas (TNF receptor superfamily, member 6)
• FAS
• FASLG receptor
• TNF receptor superfamily member 6
• APO-1 cell surface antigen
• apoptosis antigen 1
• CD95 antigen
• tumor necrosis factor receptor superfamily, member 6
• Fas AMA
• Apo-1 antigen
• apoptosis-mediating surface antigen FAS
• apoptosis signaling receptor FAS
• mutant tumor necrosis receptor superfamily member 6
• tumor necrosis factor receptor superfamily member 6

edit

Language	Label	Description	Also known as
English	Fas cell surface death receptor	mammalian protein found in Homo sapiens	Fas (TNF receptor superfamily, member 6) FAS FASLG receptor TNF receptor superfamily member 6 APO-1 cell surface antigen apoptosis antigen 1 CD95 antigen tumor necrosis factor receptor superfamily, member 6 Fas AMA Apo-1 antigen apoptosis-mediating surface antigen FAS apoptosis signaling receptor FAS mutant tumor necrosis receptor superfamily member 6 tumor necrosis factor receptor superfamily member 6

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P25445

part of

fas receptor

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25445

Death-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25445

Fas receptor, death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fas receptor, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TNFR/NGFR cysteine-rich region, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

Fas receptor.png
3,200 × 2,400; 1.84 MB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P25445

encoded by

FAS

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P25445

molecular function

kinase binding

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

protein binding

determination method

IPI

18 references

retrieved

8 April 2019

stated in

Whole-exome-sequencing-based discovery of human FADD deficiency

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Inhibition of Daxx-mediated apoptosis by heat shock protein 27

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Negative regulation of Fas-mediated apoptosis by FAP-1 in human cancer cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Yes and PI3K bind CD95 to signal invasion of glioblastoma

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

The role of receptor internalization in CD95 signaling

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

transmembrane signaling receptor activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEA

signal transducer activity

determination method

TAS

2 references

retrieved

17 October 2017

stated in

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

TAS

retrieved

17 October 2017

stated in

Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

TAS

identical protein binding

determination method

IPI

3 references

retrieved

8 April 2019

stated in

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

retrieved

8 April 2019

stated in

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IPI

tumor necrosis factor-activated receptor activity

determination method

IBA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IBA

tumor necrosis factor binding

determination method

IBA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IBA

calmodulin binding

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEA

retrieved

8 April 2019

stated in

Structural insights into the mechanism of calmodulin binding to death receptors

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IDA

signaling receptor activity

determination method

NAS

TAS

2 references

retrieved

8 April 2019

stated in

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

retrieved

8 April 2019

stated in

Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

NAS

cell component

CD95 death-inducing signaling complex

determination method

IDA

IEA

2 references

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

retrieved

17 October 2017

stated in

The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IDA

membrane

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEA

extracellular region

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEA

cell surface

determination method

IDA

IEA

2 references

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

retrieved

17 October 2017

stated in

Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IDA

extracellular exosome

determination method

IDA

1 reference

retrieved

17 October 2017

stated in

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IDA

integral component of membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEA

plasma membrane

determination method

IDA

TAS

IMP

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

retrieved

8 April 2019

stated in

Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IMP

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IDA

integral component of plasma membrane

determination method

IBA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IBA

external side of plasma membrane

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

death-inducing signaling complex

determination method

IDA

2 references

retrieved

8 April 2019

stated in

PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IDA

retrieved

8 April 2019

stated in

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IDA

membrane raft

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IDA

cytosol

determination method

IDA

NAS

2 references

retrieved

8 April 2019

stated in

Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

NAS

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IDA

nuclear body

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IDA

mitochondrion

determination method

IBA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IBA

cell surface

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IDA

CD95 death-inducing signaling complex

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IDA

extracellular exosome

determination method

HDA

1 reference

retrieved

8 April 2019

stated in

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

HDA

biological process

renal system process

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

activation-induced cell death of T cells

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

tumor necrosis factor-mediated signaling pathway

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

T cell homeostasis

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

cellular response to mechanical stimulus

determination method

IEP

1 reference

retrieved

8 April 2019

stated in

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEP

circadian rhythm

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

apoptotic signaling pathway

determination method

TAS

IEA

2 references

retrieved

17 October 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

TAS

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

positive regulation of extrinsic apoptotic signaling pathway

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

apoptotic process

determination method

IDA

TAS

IEA

5 references

retrieved

8 April 2019

stated in

p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expression

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

retrieved

8 April 2019

stated in

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEA

retrieved

8 April 2019

stated in

Effect of age and apoptosis on the mouse homologue of the huWRN gene

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IDA

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

determination method

TAS

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

TAS

spleen development

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

negative thymic T cell selection

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

regulation of lymphocyte differentiation

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

necroptotic signaling pathway

determination method

IEA

IMP

2 references

retrieved

17 October 2017

stated in

Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IMP

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

motor neuron apoptotic process

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

inflammatory response

determination method

IBA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IBA

regulation of myeloid cell differentiation

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

protein homooligomerization

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

response to toxic substance

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

B cell mediated immunity

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

neuron apoptotic process

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

positive regulation of protein homooligomerization

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

cellular response to lithium ion

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

positive regulation of lymphocyte apoptotic process

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

negative regulation of apoptotic process

determination method

TAS

IEA

2 references

retrieved

17 October 2017

stated in

Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

TAS

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

immune response

determination method

IBA

IEA

2 references

retrieved

17 October 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

retrieved

17 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IBA

gene expression

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

cellular response to hyperoxia

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IMP

negative regulation of B cell activation

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

response to glucocorticoid

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

extrinsic apoptotic signaling pathway in absence of ligand

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

inflammatory cell apoptotic process

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

immunoglobulin production

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

signal transduction

determination method

TAS

IEA

2 references

retrieved

8 April 2019

stated in

Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEA

hepatocyte apoptotic process

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

response to lipopolysaccharide

determination method

IBA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IBA

extrinsic apoptotic signaling pathway

determination method

IEA

IMP

2 references

retrieved

17 October 2017

stated in

Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IMP

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

regulation of apoptotic process

determination method

NAS

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

retrieved

8 April 2019

stated in

Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

NAS

positive regulation of apoptotic process

determination method

IMP

IDA

2 references

retrieved

8 April 2019

stated in

The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IMP

retrieved

8 April 2019

stated in

Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IDA

regulation of cell population proliferation

determination method

IBA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IBA

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

multicellular organism development

determination method

IBA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IBA

extrinsic apoptotic signaling pathway via death domain receptors

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445

determination method

IEA

positive regulation of protein phosphorylation

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IMP

regulation of stress-activated MAPK cascade

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IMP

cellular response to amino acid starvation

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IMP

Fas signaling pathway

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IMP

positive regulation of apoptotic signaling pathway

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IMP

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IMP

immune response

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IEA

negative regulation of apoptotic process

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

protein-containing complex assembly

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

apoptotic signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

TAS

extrinsic apoptotic signaling pathway

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths

GOA

curator

UniProt

UniProt protein ID

P25445

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IMP

necroptotic signaling pathway

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445

determination method

IMP

Gene Atlas image

PBB GE FAS 204780 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

Death domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25445

TNFR/NGFR cysteine-rich region

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25445

Fas receptor, N-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25445

Fas receptor, death domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25445

Identifiers

RefSeq protein ID

NP_000034

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

355

NP_001307548

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

355

NP_690610

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

355

NP_690611

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

355

XP_006717882

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

355

XP_011538066

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

355

XP_011538067

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

355

XP_011538068

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

355

XP_011538069

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

355

UniProt protein ID

P25445

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P25445

P25446

Ensembl protein ID

ENSP00000347426

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000347426

ENSP00000347979

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000347979

ENSP00000349896

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000349896

ENSP00000420975

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000420975

ENSP00000422453

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000422453

ENSP00000423755

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000423755

ENSP00000424113

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000424113

ENSP00000425159

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000425159

ENSP00000345601

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000345601

ENSP00000477997

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000477997

ENSP00000498466

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000498466

Freebase ID

/m/026cdwv

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

3031857

0 references

OpenAlex ID

C3031857

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1DDF

1 reference

stated in

UniProt

UniProt protein ID

P25445

retrieved

9 August 2016

language of work or name

English

3EWT

1 reference

stated in

UniProt

UniProt protein ID

P25445

retrieved

9 August 2016

language of work or name

English

3EZQ

1 reference

stated in

UniProt

UniProt protein ID

P25445

retrieved

9 August 2016

language of work or name

English

3THM

1 reference

stated in

UniProt

UniProt protein ID

P25445

retrieved

9 August 2016

language of work or name

English

3TJE

1 reference

stated in

UniProt

UniProt protein ID

P25445

retrieved

9 August 2016

language of work or name

English

2NA7

1 reference

stated in

UniProt

UniProt protein ID

P25445

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(14 entries)

edit

• cswiki Fas receptor
• cywiki FAS
• dewiki Fas-Rezeptor
• enwiki Fas receptor
• eswiki Receptor FAS
• fawiki گیرنده فاس
• frwiki Récepteur Fas
• glwiki Receptor Fas
• idwiki CD95
• itwiki Recettore Fas
• jawiki Fas受容体
• ruwiki Fas-рецептор
• ttwiki FAS (ген)
• ukwiki FAS (ген)

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q1649375&oldid=2022903372"