The influence of proline isomerization on potency and stability of anti-HIV antibody 10E8 (Q99637166)

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26 September 2020

title

The influence of proline isomerization on potency and stability of anti-HIV antibody 10E8 (English)

1 reference

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26 September 2020

author name string

Miklos Guttman

1

1 reference

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26 September 2020

Neal N Padte

2

1 reference

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26 September 2020

Yaoxing Huang

3

1 reference

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26 September 2020

Jian Yu

4

1 reference

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26 September 2020

Gabriel J Rocklin

5

1 reference

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26 September 2020

Brian D Weitzner

6

1 reference

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26 September 2020

Michele Scian

7

1 reference

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26 September 2020

David D Ho

8

1 reference

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26 September 2020

Kelly K Lee

9

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26 September 2020

publication date

31 August 2020

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26 September 2020

1 reference

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26 September 2020

volume

10

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26 September 2020

issue

1

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26 September 2020

page(s)

14313

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The impact of proline isomerization on antigen binding and the analytical profile of a trispecific anti-HIV antibody

26 September 2020

cites work

1 reference

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Overcoming the Multiple-Monomeric-Peak Profile of Broadly Neutralizing HIV-1 Antibody 10E8 with a Unique Size-Exclusion-Chromatography Method

10 February 2021

1 reference

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Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections.

10 February 2021

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Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.

10 February 2021

1 reference

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Initiation of prolyl cis-trans isomerisation in the CDR-H3 loop of an antibody in response to antigen binding

10 February 2021

1 reference

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10 February 2021

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10 February 2021

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Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.

10 February 2021

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Changes in Structure and Antigenicity of HIV-1 Env Trimers Resulting from Removal of a Conserved CD4 Binding Site-Proximal Glycan.

10 February 2021

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Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity

10 February 2021

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Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

10 February 2021

1 reference

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Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

10 February 2021

1 reference

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Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

10 February 2021

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PyIgClassify: a database of antibody CDR structural classifications

10 February 2021

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Rational design and characterization of the novel, broad and potent bispecific HIV-1 neutralizing antibody iMabm36.

10 February 2021

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Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41.

10 February 2021

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bNAber: database of broadly neutralizing HIV antibodies

10 February 2021

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Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

10 February 2021

1 reference

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Bispecific antibodies directed to CD4 domain 2 and HIV envelope exhibit exceptional breadth and picomolar potency against HIV-1

10 February 2021

1 reference

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Minute time scale prolyl isomerization governs antibody recognition of an intrinsically disordered immunodominant epitope

10 February 2021

1 reference

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All-atom ensemble modeling to analyze small-angle x-ray scattering of glycosylated proteins

10 February 2021

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Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency

10 February 2021

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

10 February 2021

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Aromatic-proline interactions: electronically tunable CH/π interactions

10 February 2021

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Structure-guided alterations of the gp41-directed HIV-1 broadly neutralizing antibody 2F5 reveal new properties regarding its neutralizing function

10 February 2021

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A propensity scale for type II polyproline helices (PPII): aromatic amino acids in proline-rich sequences strongly disfavor PPII due to proline-aromatic interactions

10 February 2021

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10 February 2021

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10 February 2021

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10 February 2021

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Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

10 February 2021

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10 February 2021

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10 February 2021

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10 February 2021

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Interactions between Lipids and Human Anti-HIV Antibody 4E10 Can Be Reduced without Ablating Neutralizing Activity

10 February 2021

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A summary of the measured pK values of the ionizable groups in folded proteins

10 February 2021

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Engineering therapeutic monoclonal antibodies

10 February 2021

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Specificity of immobilized porcine pepsin in H/D exchange compatible conditions

10 February 2021

1 reference

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10 February 2021

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Enhanced stability of cis Pro-Pro peptide bond in Pro-Pro-Phe sequence motif

10 February 2021

1 reference

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Antibody Recognition of a Flexible Epitope at the DNA Binding Site of the Human Papillomavirus Transcriptional Regulator E2†

10 February 2021

1 reference

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Effects of i and i+3 residue identity on cis-trans isomerism of the aromatic(i+1)-prolyl(i+2) amide bond: implications for type VI beta-turn formation

10 February 2021

1 reference

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Statistically significant dependence of the Xaa-Pro peptide bond conformation on secondary structure and amino acid sequence

10 February 2021

1 reference

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Native state proline isomerization: an intrinsic molecular switch

10 February 2021

1 reference

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Proline cis-trans isomerization and protein folding

10 February 2021

1 reference

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10 February 2021

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10 February 2021

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10 February 2021

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Side-chain effects on peptidyl-prolyl cis/trans isomerisation.

10 February 2021

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Local control of peptide conformation: stabilization of cis proline peptide bonds by aromatic proline interactions

10 February 2021

1 reference

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10 February 2021

1 reference

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Multiple cis-trans conformers of the prolactin receptor proline-rich motif (PRM) peptide detected by reverse-phase HPLC, CD and NMR spectroscopy

10 February 2021

1 reference

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Stabilization of a type VI turn in a family of linear peptides in water solution

10 February 2021

1 reference

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Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity

10 February 2021

1 reference

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Folding of immunogenic peptide fragments of proteins in water solution. I. Sequence requirements for the formation of a reverse turn

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7458915

PRIMUS: a Windows PC-based system for small-angle scattering data analysis

10 February 2021

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-020-71184-7

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/S41598-020-71184-7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32868832%20AND%20SRC:MED&resulttype=core&format=json

26 September 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32868832%20AND%20SRC:MED&resulttype=core&format=json

26 September 2020

1 reference