The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19) (Q99213575)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32899231%20AND%20SRC:MED&resulttype=core&format=json

11 September 2020

title

The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19) (English)

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11 September 2020

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1

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11 September 2020

Alan G Raetz

4

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11 September 2020

Ai-Ming Yu

5

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11 September 2020

author name string

Cristabelle De Souza

2

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11 September 2020

Jyoti Batra

3

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11 September 2020

publication date

3 September 2020

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International Journal of Molecular Sciences

11 September 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32899231%20AND%20SRC:MED&resulttype=core&format=json

11 September 2020

volume

21

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11 September 2020

issue

17

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Creative Commons Attribution 4.0 International

11 September 2020

copyright license

start time

3 September 2020

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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Fatal cytokine release syndrome with chimeric anti-CD20 monoclonal antibody rituximab in a 71-year-old patient with chronic lymphocytic leukemia

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Covid-19 and thrombosis: what do we know about the risks and treatment?

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Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury

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Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

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Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

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Heme oxygenase-1 and anti-inflammatory M2 macrophages

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Available Evidence and Ongoing Clinical Trials of Remdesivir: Could It Be a Promising Therapeutic Option for COVID-19?

21 October 2020

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Remdesivir: Review of pharmacology, pre-clinical data and emerging clinical experience for COVID-19

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SARS-CoV-2 viral load and antibody responses: the case for convalescent plasma therapy

21 October 2020

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Rapid recovery of a SARS-CoV-2 infected X-linked agammaglobulinemia patient after infusion of COVID-19 convalescent plasma

21 October 2020

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21 October 2020

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21 October 2020

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21 October 2020

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21 October 2020

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21 October 2020

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Dose rationale for favipiravir use in patients infected with SARS-CoV-2

21 October 2020

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Continuous hydroxychloroquine or colchicine therapy does not prevent infection with SARS-CoV-2: Insights from a large healthcare database analysis

21 October 2020

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COVID-19 and its implications for thrombosis and anticoagulation

21 October 2020

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Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

21 October 2020

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Coagulation abnormalities and thrombosis in patients with COVID-19

21 October 2020

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Venous Thrombosis Among Critically Ill Patients With Coronavirus Disease 2019 (COVID-19)

21 October 2020

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Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice

21 October 2020

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Association among genetic polymorphisms of GSTP1, HO-1, and SOD-3 and chronic obstructive pulmonary disease susceptibility

21 October 2020

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Heme Oxygenases in Cardiovascular Health and Disease

21 October 2020

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Heme and HO-1 Inhibition of HCV, HBV, and HIV.

21 October 2020

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Into the eye of the cytokine storm

21 October 2020

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Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3-RXR axis in asthma

21 October 2020

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

ER stress-induced cell death mechanisms

21 October 2020

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Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

21 October 2020

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Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release

21 October 2020

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The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

21 October 2020

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SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

21 October 2020

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Induction of heme oxygenase-1 expression inhibits platelet-dependent thrombosis

21 October 2020

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Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Genetic variation in heme oxygenase 1 (HMOX1) and the risk of recurrent venous thromboembolism

21 October 2020

1 reference

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Heme oxygenase-1 as a protective gene.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Vascular heme oxygenase-1 induction suppresses microvascular thrombus formation in vivo

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Carbon monoxide inhibits capacitative calcium entry in human platelets

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Carbon monoxide and bile pigments: surprising mediators of vascular function

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Modulation of endothelial cell apoptosis by heme oxygenase-1-derived carbon monoxide

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Carbon monoxide increases macrophage bacterial clearance through Toll-like receptor (TLR)4 expression.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Biliverdin protects against polymicrobial sepsis by modulating inflammatory mediators

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

The BET Bromodomain Inhibitor OTX015 Synergizes with Targeted Agents in Multiple Myeloma

21 October 2020

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BRD4 and Cancer: going beyond transcriptional regulation

21 October 2020

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Epigenetic drugs against cancer: an evolving landscape

21 October 2020

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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

21 October 2020

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DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

21 October 2020

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Promising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK-8628 in malignant pleural mesothelioma xenografts

21 October 2020

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Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia

21 October 2020

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Pharmacology and therapeutic potential of sigma(1) receptor ligands

21 October 2020

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The pharmacology of sigma-1 receptors

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Allosteric Modulators of Sigma-1 Receptor: A Review

21 October 2020

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A Supercritical CO2 Extract of Neem Leaf (A. indica) and its Bioactive Liminoid, Nimbolide, Suppresses Colon Cancer in Preclinical Models by Modulating Pro-inflammatory Pathways.

21 October 2020

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Antiangiogenic Effects and Therapeutic Targets of Azadirachta indica Leaf Extract in Endothelial Cells

21 October 2020

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The Highly Pure Neem Leaf Extract, SCNE, Inhibits Tumorigenesis in Oral Squamous Cell Carcinoma via Disruption of Pro-tumor Inflammatory Cytokines and Cell Signaling

21 October 2020

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Effects of Azardirachta indica on Vascular Endothelial Growth Factor and Cytokines in Diabetic Deep Wound

21 October 2020

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Anti dermatophytic activity of Azardirachta indica (neem) by invitro study

21 October 2020

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Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment

21 October 2020

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Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

21 October 2020

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection

21 October 2020

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Inhibitory potential of neem (Azadirachta indica Juss) leaves on dengue virus type-2 replication

21 October 2020

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The in vitro antiviral property of Azadirachta indica polysaccharides for poliovirus

21 October 2020

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'In vitro' antiviral activity of neem (Azadirachta indica. A. Juss) leaf extract against group B coxsackieviruses.

21 October 2020

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Water-extracted polysaccharides from Azadirachta indica leaves: Structural features, chemical modification and anti-bovine herpesvirus type 1 (BoHV-1) activity.

21 October 2020

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Antiviral activity and mode of action of extracts from neem seed kernel against duck plague virus in vitro1.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Medicinal properties of fractionated acetone/water neem [Azadirachta indica] leaf extract from Nigeria: a review.

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Novel molecular targets of Azadirachta indica associated with inhibition of tumor growth in prostate cancer

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

A computational prediction of SARS-CoV-2 structural protein inhibitors from Azadirachta indica (Neem)

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Identification of a novel dual-target scaffold for 3CLpro and RdRp proteins of SARS-CoV-2 using 3D-similarity search, molecular docking, molecular dynamics and ADMET evaluation

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

21 October 2020

1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503392

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

21 October 2020

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The Association of Interleukin-6 value, Interleukin inhibitors and Outcomes of Patients with COVID-19 in New York City

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7503392

Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions reveal

10 February 2021

1 reference

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Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: results from a single Italian Centre study on tocilizumab versus standard of care

10 February 2021

0 references

Identifiers

DOI

10.3390/IJMS21176412

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32899231%20AND%20SRC:MED&resulttype=core&format=json

11 September 2020

0 references

1 reference