DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation (Q28830958)

1

0 references

Dennis L Buckley

2

0 references

Joshiawa Paulk

3

0 references

Justin M Roberts

4

0 references

Amanda Souza

5

0 references

Sirano Dhe-Paganon

6

0 references

James E Bradner

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

7

0 references

language of work or name

English

0 references

publication date

19 June 2015

0 references

published in

Science

0 references

volume

348

0 references

page(s)

1376-81

0 references

issue

6241

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Targeting bromodomains: epigenetic readers of lysine acetylation

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Suppression of inflammation by a synthetic histone mimic

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Selective inhibition of BET bromodomains

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Identification of a primary target of thalidomide teratogenicity

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Function and regulation of cullin-RING ubiquitin ligases

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Integration, scaling, space-group assignment and post-refinement

16 March 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAB1433

Phasercrystallographic software

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAB1433

Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAB1433

PHENIX: a comprehensive Python-based system for macromolecular structure solution

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAB1433

Coot: model-building tools for molecular graphics

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAB1433

A tissue-specific atlas of mouse protein phosphorylation and expression

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Selective inhibition of tumor oncogenes by disruption of super-enhancers

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Targeting MYC dependence in cancer by inhibiting BET bromodomains

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Genome-wide localization of small molecules

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

BET bromodomains mediate transcriptional pause release in heart failure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Chemical genetic control of protein levels: selective in vivo targeted degradation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Chemical control of protein stability and function in living mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

Structural basis for an unexpected mode of SERM-mediated ER antagonism

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937790

The evolution of thalidomide and its IMiD derivatives as anticancer agents

26 November 2018

1 reference