NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor (Q92195187)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31867777%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

title

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor (English)

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27 April 2020

7

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Vivian Li

10

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27 April 2020

author name string

Laura Novellasdemunt

1

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27 April 2020

Anna Kucharska

2

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27 April 2020

Cara Jamieson

3

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27 April 2020

Maria Prange-Barczynska

4

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27 April 2020

Anna Baulies

5

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27 April 2020

Pedro Antas

6

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27 April 2020

Helmuth Gehart

8

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27 April 2020

Madelon M Maurice

9

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27 April 2020

publication date

23 December 2019

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27 April 2020

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27 April 2020

volume

39

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27 April 2020

issue

3

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27 April 2020

page(s)

e102771

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RNA toxicity in non-coding repeat expansion disorders

27 April 2020

cites work

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SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization

23 February 2021

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23 February 2021

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Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

23 February 2021

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A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

23 February 2021

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E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling

23 February 2021

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BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes

23 February 2021

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23 February 2021

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Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

23 February 2021

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Intestinal knockout of Nedd4 enhances growth of Apcmin tumors.

23 February 2021

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23 February 2021

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23 February 2021

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Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

23 February 2021

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Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.

23 February 2021

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The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.

23 February 2021

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The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

23 February 2021

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Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration

23 February 2021

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NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling

23 February 2021

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HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation

23 February 2021

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NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway

23 February 2021

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Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

23 February 2021

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23 February 2021

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Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase

23 February 2021

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23 February 2021

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

23 February 2021

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

23 February 2021

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23 February 2021

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23 February 2021

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

23 February 2021

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23 February 2021

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

23 February 2021

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

23 February 2021

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23 February 2021

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Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

23 February 2021

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Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development

23 February 2021

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23 February 2021

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Physiological functions of the HECT family of ubiquitin ligases

23 February 2021

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

23 February 2021

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Transcription factor achaete scute-like 2 controls intestinal stem cell fate

23 February 2021

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Crypt stem cells as the cells-of-origin of intestinal cancer

23 February 2021

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Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas

23 February 2021

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Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

23 February 2021

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Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2

23 February 2021

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Identification of stem cells in small intestine and colon by marker gene Lgr5

23 February 2021

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Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

23 February 2021

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Mitogenic influence of human R-spondin1 on the intestinal epithelium

23 February 2021

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An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells

23 February 2021

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R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

23 February 2021

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Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation

23 February 2021

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Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4.

23 February 2021

1 reference

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Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

23 February 2021

1 reference

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An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

23 February 2021

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beta-catenin is a target for the ubiquitin-proteasome pathway

23 February 2021

1 reference

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types

23 February 2021

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

23 February 2021

1 reference

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23 February 2021

Identifiers

DOI

10.15252/EMBJ.2019102771

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31867777%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31867777%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

1 reference