CFTR-PTEN-dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection (Q91593751)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31270271%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

title

CFTR-PTEN-dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection (English)

1 reference

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23 April 2020

main subject

Pseudomonas aeruginosa

1 reference

2

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23 April 2020

Ahmed M Moustafa

3

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23 April 2020

Kalle Liimatta

4

1 reference

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23 April 2020

Kira L Tomlinson

5

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23 April 2020

Clemente J Britto

6

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23 April 2020

Sara Khanal

7

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23 April 2020

José Manuel Azcona

10

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23 April 2020

Yolanda Saenz

12

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23 April 2020

Paul J Planet

13

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23 April 2020

Alice Prince

14

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23 April 2020

author name string

Sebastián A Riquelme

1

1 reference

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23 April 2020

Simren K Gill

8

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23 April 2020

Apurva Narechania

9

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23 April 2020

Emily DiMango

11

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23 April 2020

publication date

1 July 2019

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Science Translational Medicine

23 April 2020

published in

1 reference

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23 April 2020

volume

11

1 reference

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23 April 2020

issue

499

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Great phenotypic and genetic variation among successive chronic Pseudomonas aeruginosa from a cystic fibrosis patient

23 April 2020

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High-Resolution Magic Angle Spinning NMR-Based Metabolomics Revealing Metabolic Changes in Lung of Mice Infected with P. aeruginosa Consistent with the Degree of Disease Severity

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Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

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23 February 2021

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Disruption of IDH2 attenuates lipopolysaccharide-induced inflammation and lung injury in an α-ketoglutarate-dependent manner

23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity.

23 February 2021

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CFTR Modulator Therapy for Cystic Fibrosis.

23 February 2021

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IDH3 mediates apoptosis of alveolar epithelial cells type 2 due to mitochondrial Ca2+ uptake during hypocapnia

23 February 2021

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Metabolic defence against oxidative stress: the road less travelled so far.

23 February 2021

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Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion

23 February 2021

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Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginosa via Tricarboxylic Acid Cycle Control

23 February 2021

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Role of PTEN in Oxidative Stress and DNA Damage in the Liver of Whole-Body Pten Haplodeficient Mice

23 February 2021

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Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels

23 February 2021

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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

23 February 2021

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23 February 2021

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GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis.

23 February 2021

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Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

23 February 2021

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Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences

23 February 2021

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Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

23 February 2021

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23 February 2021

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Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons from Pseudomonas aeruginosa and Other Bacteria

23 February 2021

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Role of Glyoxylate Shunt in Oxidative Stress Response

23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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Pseudomonas aeruginosa MifS-MifR Two-Component System Is Specific for α-Ketoglutarate Utilization

23 February 2021

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23 February 2021

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23 February 2021

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PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism

23 February 2021

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TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

23 February 2021

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23 February 2021

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Fosfomycin and tobramycin in combination downregulate nitrate reductase genes narG and narH, resulting in increased activity against Pseudomonas aeruginosa under anaerobic conditions.

23 February 2021

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Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα).

23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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Elevated plasma succinate in PTEN, SDHB, and SDHD mutation-positive individuals

23 February 2021

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Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

23 February 2021

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23 February 2021

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Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose

23 February 2021

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Pseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lung

23 February 2021

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Hypoxia, HIF1 and glucose metabolism in the solid tumour

23 February 2021

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23 February 2021

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Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice

23 February 2021

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Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms

23 February 2021

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Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia

23 February 2021

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Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function

23 February 2021

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The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa

23 February 2021

1 reference

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Scavenging by alginate of free radicals released by macrophages

23 February 2021

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Isolation and characterization of catabolite repression control mutants of Pseudomonas aeruginosa PAO

23 February 2021

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Alginate synthesis by Pseudomonas aeruginosa: a key pathogenic factor in chronic pulmonary infections of cystic fibrosis patients

23 February 2021

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10.1126/SCITRANSLMED.AAV4634

23 February 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31270271%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31270271%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

1 reference