Recent Advances in Toll Like Receptor-Targeting Glycoconjugate Vaccines (Q89388768)

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4 April 2020

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3 November 2020

Recent Advances in Toll Like Receptor-Targeting Glycoconjugate Vaccines (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29966261%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

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2 October 2020

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3 November 2020

Qingjiang Li

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29966261%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Zhongwu Guo

series ordinal

2

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4 April 2020

publication date

29 June 2018

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4 April 2020

2 October 2020

3 November 2020

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4 April 2020

2 October 2020

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23

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issue

7

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Creative Commons Attribution

4 April 2020

copyright license

2 references

2 October 2020

3 November 2020

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Clinical evaluation of group A and group C meningococcal polysaccharide vaccines in infants

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12 December 2020

Synthetic lipopeptide analogs of bacterial lipoprotein are potent polyclonal activators for murine B lymphocytes

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12 December 2020

Serum antibodies after vaccination with Haemophilus influenzae type b capsular polysaccharide and responses to reimmunization: no evidence of immunologic tolerance or memory.

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12 December 2020

Immunogenicity of a synthetic HBsAg peptide: enhancement by conjugation to a fatty acid carrier

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12 December 2020

Purification and structural determination of nontoxic lipid A obtained from the lipopolysaccharide of Salmonella typhimurium.

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12 December 2020

Synthetic carbohydrate vaccines: synthesis and immunogenicity of Tn antigen conjugates.

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12 December 2020

Biophysical characterization of one-, two-, and three-tandem repeats of human mucin (muc-1) protein core

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12 December 2020

Interim results of a phase II multicenter clinical trial evaluating the activity of a therapeutic allogeneic melanoma vaccine (theraccine) in the treatment of disseminated malignant melanoma

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12 December 2020

Immunologic priming of young children by pneumococcal glycoprotein conjugate, but not polysaccharide, vaccines.

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12 December 2020

A randomised phase II study of sialyl-Tn and DETOX-B adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer

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12 December 2020

Synthesis of Tn and sialyl Tn antigen-lipid A analog conjugates for synthetic vaccines

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12 December 2020

Structure and specific activity of macrophage-stimulating lipopeptides from Mycoplasma hyorhinis

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12 December 2020

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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12 December 2020

Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines

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12 December 2020

Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

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12 December 2020

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12 December 2020

Toward optimized carbohydrate-based anticancer vaccines: epitope clustering, carrier structure, and adjuvant all influence antibody responses to Lewis(y) conjugates in mice

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12 December 2020

Solution and solid-support synthesis of a potential leishmaniasis carbohydrate vaccine

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12 December 2020

Toll-like receptors: critical proteins linking innate and acquired immunity

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12 December 2020

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

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12 December 2020

Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial

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Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: impact of HLA class I antigen expression on outcome.

1 reference

12 December 2020

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

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12 December 2020

Taking toll: lipid A mimetics as adjuvants and immunomodulators

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12 December 2020

Highly immunogenic and totally synthetic lipopeptides as self-adjuvanting immunocontraceptive vaccines.

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12 December 2020

MUC1-like tandem repeat proteins are broadly immunogenic in cancer patients

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12 December 2020

Toll-like receptor signalling

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12 December 2020

Prospects for total synthesis: a vision for a totally synthetic vaccine targeting epithelial tumors

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12 December 2020

Lipopeptide epitopes extended by an Nepsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Toll-like receptor-2 pathway and trigger a Th1-dependent protective immunity

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12 December 2020

Toll-like receptor control of the adaptive immune responses

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12 December 2020

A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses

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12 December 2020

Safety and immunogenicity profile of an experimental hepatitis B vaccine adjuvanted with AS04

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12 December 2020

The sweet and sour of cancer: glycans as novel therapeutic targets

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12 December 2020

Towards a Fully Synthetic Carbohydrate-Based Anticancer Vaccine: Synthesis and Immunological Evaluation of a Lipidated Glycopeptide Containing the Tumor-Associated Tn Antigen

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12 December 2020

Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer

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12 December 2020

Chemoselective assembly and immunological evaluation of multiepitopic glycoconjugates bearing clustered Tn antigen as synthetic anticancer vaccines.

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12 December 2020

Lipolanthionine peptides act as inhibitors of TLR2-mediated IL-8 secretion. Synthesis and structure-activity relationships

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12 December 2020

Synthesis and structural model of an alpha(2,6)-sialyl-t glycosylated MUC1 eicosapeptide under physiological conditions

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12 December 2020

A pilot study of the liposomal MUC1 vaccine BLP25 in prostate specific antigen failures after radical prostatectomy

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12 December 2020

A controlled clinical trial comparing the safety and immunogenicity of a new adjuvanted hepatitis B vaccine with a standard hepatitis B vaccine

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12 December 2020

Glycosylation in cellular mechanisms of health and disease

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12 December 2020

Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers

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12 December 2020

Synthesis of Glyco(lipo)peptides by Liposome-Mediated Native Chemical Ligation

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12 December 2020

Robust immune responses elicited by a fully synthetic three-component vaccine

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12 December 2020

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

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12 December 2020

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

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12 December 2020

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

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12 December 2020

Immunotherapy for cancer: synthetic carbohydrate-based vaccines

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12 December 2020

Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3.

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12 December 2020

CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : I. THE SYNTHESIS OFp-AMINOPHENOL beta-GLUCOSIDE, p-AMINOPHENOL beta-GALACTOSIDE, AND THEIR COUPLING WITH SERUM GLOBULIN.

1 reference

12 December 2020

CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : II. IMMUNOLOGICAL SPECIFICITY OF SYNTHETIC SUGAR-PROTEIN ANTIGENS.

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12 December 2020

CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : III. ACTIVE AND PASSIVE ANAPHYLAXIS WITH SYNTHETIC SUGAR-PROTEINS.

1 reference

12 December 2020

Synthesis of a monophosphoryl derivative of Escherichia coli lipid A and its efficient coupling to a tumor-associated carbohydrate antigen.

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12 December 2020

How bacterial carbohydrates influence the adaptive immune system

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12 December 2020

Structure-activity relationship of lipopeptide Group A streptococcus (GAS) vaccine candidates on toll-like receptor 2.

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12 December 2020

Structural requirement for the agonist activity of the TLR2 ligand Pam2Cys

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12 December 2020

Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides

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12 December 2020

Carbohydrate vaccines: developing sweet solutions to sticky situations?

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12 December 2020

Fully synthetic vaccines consisting of tumor-associated MUC1 glycopeptides and a lipopeptide ligand of the Toll-like receptor 2

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12 December 2020

Linear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunity

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12 December 2020

Synthesis of MUC1-lipopeptide chimeras

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12 December 2020

Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical Results

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12 December 2020

Vaccine adjuvants: putting innate immunity to work

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12 December 2020

Self-adjuvanting multicomponent cancer vaccine candidates combining per-glycosylated MUC1 glycopeptides and the Toll-like receptor 2 agonist Pam3CysSer.

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12 December 2020

Towards a fully synthetic MUC1-based anticancer vaccine: efficient conjugation of glycopeptides with mono-, di-, and tetravalent lipopeptides using click chemistry

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12 December 2020

Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response

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12 December 2020

Carbohydrate-monophosphoryl lipid a conjugates are fully synthetic self-adjuvanting cancer vaccines eliciting robust immune responses in the mouse

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12 December 2020

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design

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12 December 2020

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

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12 December 2020

Overview and outlook of Toll-like receptor ligand-antigen conjugate vaccines.

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12 December 2020

Synthesis and immunological evaluation of self-assembling and self-adjuvanting tricomponent glycopeptide cancer-vaccine candidates

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12 December 2020

Novel toll-like receptor 2 ligands for targeted pancreatic cancer imaging and immunotherapy.

1 reference

12 December 2020

Synthesis and immunological evaluation of a MUC1 glycopeptide incorporated into l-rhamnose displaying liposomes

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12 December 2020

Mechanisms of action of adjuvants

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12 December 2020

Protein carriers of conjugate vaccines: characteristics, development, and clinical trials

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12 December 2020

Synthetic multivalent glycopeptide-lipopeptide antitumor vaccines: impact of the cluster effect on the killing of tumor cells

1 reference

12 December 2020

Synthesis and evaluation of monophosphoryl lipid A derivatives as fully synthetic self-adjuvanting glycoconjugate cancer vaccine carriers

1 reference

12 December 2020

Immune and anticancer responses elicited by fully synthetic aberrantly glycosylated MUC1 tripartite vaccines modified by a TLR2 or TLR9 agonist

1 reference

12 December 2020

N-tetradecylcarbamyl lipopeptides as novel agonists for Toll-like receptor 2.

1 reference

12 December 2020

Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

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12 December 2020

CpG-loaded multifunctional cationic nanohydrogel particles as self-adjuvanting glycopeptide antitumor vaccines

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12 December 2020

Protein glycosylation in cancer

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12 December 2020

Development of Globo-H cancer vaccine

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12 December 2020

Guiding principles in the design of molecular bioconjugates for vaccine applications

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12 December 2020

Design, synthesis and immunological evaluation of 1,2,3-triazole-tethered carbohydrate-Pam3Cys conjugates as TLR2 agonists

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12 December 2020

Immunological Features and Clinical Benefits of Conjugate Vaccines against Bacteria

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12 December 2020

Synthetic self-adjuvanting glycopeptide cancer vaccines

1 reference

12 December 2020

Synthesis of a Liposomal MUC1 Glycopeptide-Based Immunotherapeutic and Evaluation of the Effect of l-Rhamnose Targeting on Cellular Immune Responses

1 reference

12 December 2020

A Fully Synthetic Self-Adjuvanting Globo H-Based Vaccine Elicited Strong T Cell-Mediated Antitumor Immunity.

1 reference

12 December 2020

Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis

1 reference

12 December 2020

Synthetic MUC1 Antitumor Vaccine Candidates with Varied Glycosylation Pattern Bearing R/S-configured Pam3 CysSerLys4

1 reference

12 December 2020

A Semisynthetic Approach to New Immunoadjuvant Candidates: Site-Selective Chemical Manipulation of Escherichia coli Monophosphoryl Lipid A.

1 reference

12 December 2020

TLR10 suppresses the activation and differentiation of monocytes with effects on DC-mediated adaptive immune responses

1 reference

12 December 2020

The Novel Toll-Like Receptor 2 Agonist SUP3 Enhances Antigen Presentation and T Cell Activation by Dendritic Cells.

1 reference

12 December 2020

Immunogenicity of a Fully Synthetic MUC1 Glycopeptide Antitumor Vaccine Enhanced by Poly(I:C) as a TLR3-Activating Adjuvant.

1 reference

12 December 2020

Progress in the synthesis and biological evaluation of lipid A and its derivatives.

1 reference

12 December 2020

Synthesis and Evaluation of GM2-Monophosphoryl Lipid A Conjugate as a Fully Synthetic Self-Adjuvant Cancer Vaccine.

1 reference

12 December 2020

Ni(II) interaction with a peptide model of the human TLR4 ectodomain

1 reference

12 December 2020

Development of Clickable Monophosphoryl Lipid A Derivatives toward Semisynthetic Conjugates with Tumor-Associated Carbohydrate Antigens.

1 reference

12 December 2020

Synthesis and Immunological Comparison of Differently Linked Lipoarabinomannan Oligosaccharide-Monophosphoryl Lipid A Conjugates as Antituberculosis Vaccines.

1 reference

12 December 2020

TLR Agonist Conjugation: A Chemical Perspective.

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12 December 2020

Potential targets for next generation anti-microbial glycoconjugate vaccines.

1 reference

12 December 2020

Augmenting Vaccine Immunogenicity through the Use of Natural Human Anti-rhamnose Antibodies

1 reference

12 December 2020

10.3390/MOLECULES23071583

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29966261%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29966261%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

PubMed publication ID

29966261

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