The sweet and sour of cancer: glycans as novel therapeutic targets (Q34439560)

2 August 2017

title

The sweet and sour of cancer: glycans as novel therapeutic targets (English)

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2 August 2017

Mark M Fuster

1

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2 August 2017

Jeffrey D Esko

series ordinal

2

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2 August 2017

publication date

1 July 2005

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2 August 2017

language of work or name

English

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published in

Nature Reviews Cancer

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2 August 2017

volume

5

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2 August 2017

issue

7

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2 August 2017

page(s)

526-542

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publication type of scholarly work

2 August 2017

review article

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Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc

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Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena

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Lipid rafts and the local density of ErbB proteins influence the biological role of homo- and heteroassociations of ErbB2.

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Molecular diversity of heparan sulfate

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Functions of cell surface heparan sulfate proteoglycans

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The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer

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Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.

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Simpson Golabi Behmel syndrome: progress toward understanding the molecular basis for overgrowth, malformation, and cancer predisposition

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Glypicans in growth control and cancer

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Signaling Properties of Hyaluronan Receptors

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Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice

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Regulation of Multidrug Resistance in Cancer Cells by Hyaluronan

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O-Linked N-Acetylglucosamine and Cancer: Messages from the Glycosylation of C-Myc

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Induction of CA125-specific B and T cell responses in patients injected with MAb-B43.13--evidence for antibody-mediated antigen-processing and presentation of CA125 in vivo

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Reevaluation of the cellular immune response in breast cancer patients vaccinated with MUC1

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Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer

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Recombinant antibodies in the immunotherapy of neuroblastoma: perspectives of new developments

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Immunotherapy of advanced breast cancer with a heterophilic ganglioside (NeuGcGM3) cancer vaccine

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Polyamine metabolism and cancer.

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Tumor attenuation by combined heparan sulfate and polyamine depletion.

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Inhibition of tumor growthin vivo by hyaluronan oligomers

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UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,6 N-acetylglucosaminyltransferase V (Mgat5) deficient mice

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Aberrant glycosylation of E-cadherin enhances cell-cell binding to suppress metastasis

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Cell adhesion system and human cancer morphogenesis

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Polysialic acid directs tumor cell growth by controlling heterophilic neural cell adhesion molecule interactions.

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Polysialyltransferases: major players in polysialic acid synthesis on the neural cell adhesion molecule

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Cell surface alpha 2,6 sialylation affects adhesion of breast carcinoma cells

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A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase

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Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA.

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Focal adhesion regulation of cell behavior.

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Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions

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A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formation

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Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers

31 March 2020

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Cooperation of syndecan-2 and syndecan-4 among cell surface heparan sulfate proteoglycans in the actin cytoskeletal organization of Lewis lung carcinoma cells

31 March 2020

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Heparan sulfate proteoglycans of Ras-transformed 3T3 or neuroblastoma cells. Differing functions in adhesion on fibronectin

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Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis

31 March 2020

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Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells

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Syndecans in tumor cell adhesion and signaling

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The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells

31 March 2020

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Heparan sulfate proteoglycans in invasion and metastasis

31 March 2020

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Cell surface chondroitin sulfate proteoglycans in tumor cell adhesion, motility and invasion

31 March 2020

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A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion

31 March 2020

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A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

31 March 2020

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CD44 is the principal cell surface receptor for hyaluronate

31 March 2020

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Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin

31 March 2020

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Generation of artificial proteoglycans containing glycosaminoglycan-modified CD44. Demonstration of the interaction between rantes and chondroitin sulfate

31 March 2020

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Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis

31 March 2020

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Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis

31 March 2020

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Molecular properties and involvement of heparanase in cancer progression and normal development

31 March 2020

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Perlecan and tumor angiogenesis

31 March 2020

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Suppression of invasive behavior of melanoma cells by stable expression of anti-sense perlecan cDNA.

31 March 2020

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Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

Suppression of tumor growth and metastasis in Mgat5-deficient mice

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The joys of HexNAc. The synthesis and function of N- and O-glycan branches

31 March 2020

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Selective inhibition of polysialyltransferase ST8SiaII by unnatural sialic acids

31 March 2020

1 reference

An expanding role for antithrombotic therapy in cancer patients

31 March 2020

1 reference

Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells

31 March 2020

1 reference

Glycosaminoglycans in human breast cancer

31 March 2020

1 reference

Heparinlike molecules with anticoagulant activity are synthesized by cultured endothelial cells

31 March 2020

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Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice

31 March 2020

1 reference

Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo

31 March 2020

1 reference

Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior

31 March 2020

1 reference

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

31 March 2020

1 reference

Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties

31 March 2020

1 reference

Heparin derivatives as angiogenesis inhibitors

31 March 2020

1 reference

Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds

31 March 2020

1 reference

Biosynthetic oligosaccharide libraries for identification of protein-binding heparan sulfate motifs. Exploring the structural diversity by screening for fibroblast growth factor (FGF)1 and FGF2 binding

31 March 2020

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Undersulfated, low-molecular-weight glycol-split heparin as an antiangiogenic VEGF antagonist

31 March 2020

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The role of integrins in tumor angiogenesis

31 March 2020

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Are selectins involved in metastasis?

31 March 2020

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Pictures in molecular medicine: three-dimensional visualization of intravascular tumor cells in mice

31 March 2020

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P-selectin deficiency attenuates tumor growth and metastasis

31 March 2020

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Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis

31 March 2020

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Involvement of carbohydrate antigen sialyl Lewis(x) in colorectal cancer metastasis

31 March 2020

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Histopathological subtypes and prognosis of gastric cancer are correlated with the expression of mucin-associated sialylated antigens: Sialosyl-Lewis(a), Sialosyl-Lewis(x) and sialosyl-Tn

31 March 2020

1 reference

Involvement of chemokine receptors in breast cancer metastasis

31 March 2020

1 reference

Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling.

31 March 2020

1 reference

New aspects of siglec binding specificities, including the significance of fucosylation and of the sialyl-Tn epitope. Sialic acid-binding immunoglobulin superfamily lectins

31 March 2020

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Galectins as modulators of tumour progression

31 March 2020

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Correlation between spontaneous metastatic potential, platelet-aggregating activity of cell surface extracts, and cell surface sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma cell line

31 March 2020

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Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis

31 March 2020

1 reference

Anti-P-selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear

31 March 2020

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Design and synthesis of sialyl Lewis(x) mimics as E- and P-selectin inhibitors

31 March 2020

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A novel glycosulfopeptide binds to P-selectin and inhibits leukocyte adhesion to P-selectin

31 March 2020

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Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans

31 March 2020

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Arrays for the combinatorial exploration of cell adhesion

31 March 2020

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Expression patterns of alpha 2,3-sialyltransferases and alpha 1,3-fucosyltransferases determine the mode of sialyl Lewis X inhibition by disaccharide decoys.

31 March 2020

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Fucosylation of Disaccharide Precursors of Sialyl LewisX Inhibit Selectin-mediated Cell Adhesion

31 March 2020

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L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis

31 March 2020

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Endothelial and epithelial expression of sialyl Lewisx and sialyl Lewisa in lesions of breast carcinoma

31 March 2020

1 reference

Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity

31 March 2020

1 reference

Biological therapy of colorectal cancer

31 March 2020

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Use of surrogate antigens as vaccines against cancer

31 March 2020

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Modulating cell surface immunoreactivity by metabolic induction of unnatural carbohydrate antigens

31 March 2020

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Gangliosides inhibit the development from monocytes to dendritic cells

31 March 2020

1 reference

Mechanisms of ganglioside inhibition of APC function

31 March 2020

1 reference

Carbohydrate vaccines in cancer: immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man.

31 March 2020

1 reference

Delivery of c-myb antisense oligodeoxynucleotides to human neuroblastoma cells via disialoganglioside GD(2)-targeted immunoliposomes: antitumor effects.

31 March 2020

1 reference

Difference in prognostic value between sialyl Lewis(a) and sialyl Lewis(x) antigen levels in the preoperative serum of gastric cancer patients

31 March 2020

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The cancer antigen CA125 represents a novel counter receptor for galectin-1.

31 March 2020

1 reference

Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue

31 March 2020

1 reference

MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion

31 March 2020

1 reference

Expanding the diversity of unnatural cell-surface sialic acids

31 March 2020

1 reference

Cell surface engineering by a modified Staudinger reaction

31 March 2020

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Targeting glycosylation as a therapeutic approach

31 March 2020

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Cancer Metastasis: A Search for Therapeutic Inhibition

31 March 2020

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Chemical remodelling of cell surfaces in living animals

31 March 2020

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Galectin-3 and metastasis

31 March 2020

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Stable transfection of a glypican-1 antisense construct decreases tumorigenicity in PANC-1 pancreatic carcinoma cells

31 March 2020

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Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy.

31 March 2020

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Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma

31 March 2020

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Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin

31 March 2020

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Proteoglycans in human malignant mesothelioma. Stimulation of their synthesis induced by epidermal, insulin and platelet-derived growth factors involves receptors with tyrosine kinase activity.

31 March 2020

1 reference

Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1649

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Dimensions Publication ID

2 August 2017

1010880720

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