Methyl-methoxylpyrrolinone and flavinium nucleus binding signatures on falcipain-2 active site (Q87511243)

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12 March 2020

title

Methyl-methoxylpyrrolinone and flavinium nucleus binding signatures on falcipain-2 active site (English)

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12 March 2020

author name string

Olaposi I Omotuyi

series ordinal

1

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publication date

6 August 2014

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Journal of Molecular Modeling

12 March 2020

published in

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volume

20

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issue

8

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page(s)

2386

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Flavonoids: a review of probable mechanisms of action and potential applications

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The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family

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Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II.

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Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum

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Falcipain-2 inhibitors

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12 December 2020

The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif

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The joint toxicity of type I, II, and nonester pyrethroid insecticides.

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Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity ‡

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Total synthesis and antimalarial activity of symplostatin 4

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Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium

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The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains

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New tricks for modelers from the crystallography toolkit: the particle mesh Ewald algorithm and its use in nucleic acid simulations

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The effect of multiple substituents on sandwich and T-shaped pi-pi interactions

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Structural and functional characterization of Falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum

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The Ionic and hydrophobic interactions are required for the auto activation of cysteine proteases of Plasmodium falciparum

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Model Studies on Protein Side Chain Modification by 4-Oxo-2-nonenal

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Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.

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Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library

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Cysteine protease inhibition by nitrile-based inhibitors: a computational study

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Dynamical footprint of falcipain-2 catalytic triad in hemoglobin-β-bound state

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12 December 2020

The mechanism of the proton transfer: an outline

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12 December 2020

Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis

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12 December 2020

10.1007/S00894-014-2386-2

Identifiers

DOI

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12 March 2020

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