The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse (Q86883798)

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2 March 2020

title

The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse (English)

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2 March 2020

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1

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2 March 2020

Stephen Man

6

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2 March 2020

Alex Tonks

7

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2 March 2020

author name string

M N Gilmour

2

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R Reid

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S Knapper

4

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A K Burnett

5

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R L Darley

8

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2 March 2020

language of work or name

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9 March 2015

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2 March 2020

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volume

29

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2 March 2020

page(s)

1952-1954

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issue

9

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https://scigraph.springernature.com/pub.10.1038/leu.2015.62

2 March 2020

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Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors.

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PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer

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The stimulation of PD-L1-specific cytotoxic T lymphocytes can both directly and indirectly enhance antileukemic immunity

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In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors.

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Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells.

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Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

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B7-H1, a prognostic factor for patient's response to therapy of acute myeloid leukemia.

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12 December 2020

Expression of CD200 on AML blasts directly suppresses memory T-cell function.

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Cross-typic specificity and immunotherapeutic potential of a human HPV16 E7-specific CTL line.

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12 December 2020