Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase (Q85651591)

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20 February 2020

title

Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23239172%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23239172%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

2

Wojciech Rode

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23239172%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

publication date

13 December 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23239172%20AND%20SRC:MED&resulttype=core&format=json

Journal of Computer - Aided Molecular Design

20 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23239172%20AND%20SRC:MED&resulttype=core&format=json

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volume

27

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20 February 2020

issue

1

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20 February 2020

page(s)

45-66

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https://scigraph.springernature.com/pub.10.1007/s10822-012-9624-4

20 February 2020

exact match

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Tyrosine nitration affects thymidylate synthase properties.

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Thymidylate synthase inhibitors

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Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase

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Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine

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Future potential of thymidylate synthase inhibitors in cancer therapy

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Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding.

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Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

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Antifolate inhibitors of thymidylate synthase as anticancer drugs

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Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug

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NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?

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In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography

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The catalytic mechanism and structure of thymidylate synthase

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12 December 2020

10.1007/S10822-012-9624-4

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23239172%20AND%20SRC:MED&resulttype=core&format=json

journals/jcamd/JarmulaR13

20 February 2020

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

Dimensions Publication ID

28 January 2021

0 references

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