Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase (Q42780056)

7 November 2017

Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase (English)

1 reference

7 November 2017

1 reference

2

1 reference

7 November 2017

4

Wojciech Rode

1 reference

7 November 2017

1

Adam Jarmuła

1 reference

7 November 2017

Piotr Cieplak

3

1 reference

PMCID

4127429

7 November 2017

language of work or name

English

0 references

publication date

9 April 2010

1 reference

Bioorganic & Medicinal Chemistry

7 November 2017

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7 November 2017

18

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7 November 2017

10

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7 November 2017

3361-3370

1 reference

Phosphorylation of thymidylate synthase from various sources by human protein kinase CK2 and its catalytic subunits

7 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Molecular dynamics and principal components analysis of human telomeric quadruplex multimers

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Thymidylate synthase structure, function and implication in drug discovery.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Novel chemical strategies for thymidylate synthase inhibition

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie".

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Protein kinase CK2: structure, regulation and role in cellular decisions of life and death

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Thymidylate synthase as a translational regulator of cellular gene expression

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Crystal structure of a deletion mutant of human thymidylate synthase Δ (7-29) and its ternary complex with Tomudex and dUMP

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

An efficient method for sampling the essential subspace of proteins.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

VMD: visual molecular dynamics

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

The catalytic mechanism and structure of thymidylate synthase

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Ligand affinities predicted with the MM/PBSA method: dependence on the simulation method and the force field.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Exclusion of 2'-deoxycytidine 5'-monophosphate by asparagine 229 of thymidylate synthase

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127429

Theory and applications of the generalized Born solvation model in macromolecular simulations

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20430630

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Essential Dynamics: A Tool for Efficient Trajectory Compression and Management

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20430630

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMC.2010.04.019

1 reference

7 November 2017

1 reference

7 November 2017

1 reference

PMCID

4127429