Antibody-enabled small-molecule drug discovery (Q84489672)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743979%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Antibody-enabled small-molecule drug discovery (English)

1 reference

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6 February 2020

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Alastair D G Lawson

1

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6 February 2020

publication date

29 June 2012

1 reference

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Nature Reviews Drug Discovery

6 February 2020

published in

1 reference

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6 February 2020

volume

11

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6 February 2020

issue

7

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6 February 2020

page(s)

519-525

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https://scigraph.springernature.com/pub.10.1038/nrd3756

6 February 2020

exact match

0 references

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Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

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A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic α-Exosite Binding Region

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Distribution of sequence differences in influenza N9 neuraminidase of tern and whale viruses and crystallization of the whale neuraminidase complexed with antibodies.

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Structure at 2.7 A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment

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Recombinant anti-sialidase single-chain variable fragment antibody. Characterization, formation of dimer and higher-molecular-mass multimers and the solution of the crystal structure of the single-chain variable fragment/sialidase complex.

31 March 2020

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Crystal structure of the intrinsically flexible addiction antidote MazE

31 March 2020

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Toward chaperone-assisted crystallography: Protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold

31 March 2020

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Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies

31 March 2020

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Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody

31 March 2020

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Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

31 March 2020

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Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus

31 March 2020

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Structure at 2.8 A resolution of cytochrome c oxidase from Paracoccus denitrificans

31 March 2020

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Crystal structure of the amyloid-β p3 fragment provides a model for oligomer formation in Alzheimer's disease

31 March 2020

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Conversion of scFv peptide-binding specificity for crystal chaperone development

31 March 2020

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Preparation and crystallization of a human immunodeficiency virus p24-Fab complex

31 March 2020

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G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody

31 March 2020

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

31 March 2020

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31 March 2020

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Turning a protein kinase on or off from a single allosteric site via disulfide trapping

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31 March 2020

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Two-state selection of conformation-specific antibodies

31 March 2020

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31 March 2020

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Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation

31 March 2020

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Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

31 March 2020

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A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme

31 March 2020

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Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein

31 March 2020

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Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism

31 March 2020

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Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes

31 March 2020

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Allosteric proteins and cellular control systems

31 March 2020

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Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

31 March 2020

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Is allostery an intrinsic property of all dynamic proteins?

31 March 2020

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Allosteric inhibition through core disruption

31 March 2020

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Targeting protein-protein interactions with small molecules: challenges and perspectives for computational binding epitope detection and ligand finding

31 March 2020

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Structural and mechanistic insight into how antibodies inhibit serine proteases.

31 March 2020

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Structural biology in fragment-based drug design

31 March 2020

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From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance

31 March 2020

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Fragment-based screening using surface plasmon resonance technology

31 March 2020

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Label-free primary screening and affinity ranking of fragment libraries using parallel analysis of protein panels

31 March 2020

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NMR-based screening in drug discovery

31 March 2020

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Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis

31 March 2020

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A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination

31 March 2020

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Trial watch: PCSK9 antibody reduces LDL cholesterol

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22743979

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fragment-based drug discovery using rational design

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22743979

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD3756

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743979%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference