Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by (Q84322701)

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scientific article published on 09 June 2011

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English	Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by	scientific article published on 09 June 2011

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scholarly article

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3 February 2020

Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters (English)

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Christopher G. Proud

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Bruno D Fonseca

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Tommy Alain

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Leona K Finestone

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Brandon P H Huang

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Mark Rolfe

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Tian Jiang

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3 February 2020

Zhong Yao

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3 February 2020

Greco Hernandez

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Christopher F Bennett

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publication date

9 June 2011

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Journal of Biological Chemistry

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286

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27111-27122

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3 February 2020

Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity and mechanism of action of some commonly used protein kinase inhibitors

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https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between the ERK and p70 S6 kinase (S6K) signaling pathways. MEK-dependent activation of S6K2 in cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin attenuates load-induced cardiac hypertrophy in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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Cardiac hypertrophy: a matter of translation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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Rheb fills a GAP between TSC and TOR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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TSC2: filling the GAP in the mTOR signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

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Protein kinase C alpha activates RAF-1 by direct phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheb binds and regulates the mTOR kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAF mutation predicts sensitivity to MEK inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current development of mTOR inhibitors as anticancer agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR and cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The selectivity of protein kinase inhibitors: a further update

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of TORC1 by Rag GTPases in nutrient response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGFR signals to mTOR through PKC and independently of Akt in glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of mTOR inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21659537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.260794

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3 February 2020

1 reference

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3 February 2020

1 reference

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3 February 2020

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