The tunable functionality of alpha,beta-unsaturated carbonyl compounds enables their differential application in biological systems (Q82692709)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20112330%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

The tunable functionality of alpha,beta-unsaturated carbonyl compounds enables their differential application in biological systems (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20112330%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Sabine Amslinger

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20112330%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

publication date

1 March 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20112330%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20112330%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20112330%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20112330%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

351-356

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20112330%20AND%20SRC:MED&resulttype=core&format=json

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

17 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

DPPH radical scavenging reaction of hydroxy- and methoxychalcones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Antioxidant activities of bile pigments

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Photoisomerization of the green fluorescence protein chromophore and the meta- and para-amino analogues.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

A 13C NMR approach to categorizing potential limitations of alpha,beta-unsaturated carbonyl systems in drug-like molecules

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Antioxidant and anti-inflammatory related activities of selected synthetic chalcones: structure-activity relationship studies using computational tools

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Formation of categories from structure-activity relationships to allow read-across for risk assessment: toxicity of alpha,beta-unsaturated carbonyl compounds

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Application of structure-activity relationships to investigate the molecular mechanisms of hepatocyte toxicity and electrophilic reactivity of alpha,beta-unsaturated aldehydes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Chalcones and their potential role in inflammation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Studies of structure-activity relationship on plant polyphenol-induced suppression of human liver cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

2',4',6'-tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-alpha-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

KB-34, a newly synthesized chalcone derivative, inhibits lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages via heme oxygenase-1 induction and blockade of activator protein-1.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Redox regulation of neuronal survival mediated by electrophilic compounds

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Role of nuclear factor-kappaB and heme oxygenase-1 in the mechanism of action of an anti-inflammatory chalcone derivative in RAW 264.7 cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Inflammation and cancer: how friendly is the relationship for cancer patients?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Helenanolide-type sesquiterpene lactones--III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Synthesis and structure-activity relationship of ethacrynic acid analogues on glutathione-s-transferase P1-1 activity inhibition

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Design and synthesis of alpha,beta-unsaturated carbonyl compounds as potential ACE inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Synthesis of peptidyl ene diones: selective inactivators of the cysteine proteinases

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Fumarates for the treatment of multiple sclerosis: potential mechanisms of action and clinical studies

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the hum

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Determination of the electrophilicity parameters of diethyl benzylidenemalonates in dimethyl sulfoxide: reference electrophiles for characterizing strong nucleophiles

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Synthesis and activity of a new series of (Z)-3-phenyl-2-benzoylpropenoic acid derivatives as aldose reductase inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Chalcone derivatives inhibit glutathione S-transferase P1-1 activity: insights into the interaction mode of alpha, beta-unsaturated carbonyl compounds

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Tyrosine kinase inhibition: an approach to drug development

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Effects of alpha-substitutions on structure and biological activity of anticancer chalcones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900499

7 January 2021

Identifiers

DOI

10.1002/CMDC.200900499

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20112330%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference