The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs (Q77182829)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724551%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

review article

1 reference

title

The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724551%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

author name string

Kusuhara H

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724551%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

Suzuki H

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724551%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

Sugiyama Y

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724551%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

language of work or name

English

0 references

publication date

1 September 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724551%20AND%20SRC:MED&resulttype=core&format=json

Journal of Pharmaceutical Sciences

3 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724551%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

volume

87

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724551%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724551%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

page(s)

1025-1040

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724551%20AND%20SRC:MED&resulttype=core&format=json

Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells

3 December 2019

cites work

1 reference

7 January 2021

ABC Transporters: From Microorganisms to Man

1 reference

7 January 2021

P-glycoproteins and multidrug resistance

1 reference

7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

7 January 2021

Genetic analysis of the multidrug transporter

1 reference

7 January 2021

P-glycoprotein and multidrug resistance

1 reference

7 January 2021

Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport.

1 reference

7 January 2021

Biology of the multidrug resistance-associated protein, MRP.

1 reference

7 January 2021

Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.

1 reference

7 January 2021

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice

1 reference

7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

7 January 2021

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

7 January 2021

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

7 January 2021

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

7 January 2021

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

1 reference

7 January 2021

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

7 January 2021

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

1 reference

7 January 2021

Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein

1 reference

7 January 2021

Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity

1 reference

7 January 2021

Involvement ofMDR1 P-glycoprotein in multifactorial resistance to methotrexate

1 reference

7 January 2021

P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake

1 reference

7 January 2021

Is the multidrug transporter a flippase?

1 reference

7 January 2021

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

7 January 2021

Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord.

1 reference

7 January 2021

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

7 January 2021

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump

1 reference

7 January 2021

Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae

1 reference

7 January 2021

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells

1 reference

7 January 2021

Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein

1 reference

7 January 2021

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1 reference

7 January 2021

Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells

1 reference

7 January 2021

Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP

1 reference

7 January 2021

ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene.

1 reference

7 January 2021

The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump

1 reference

7 January 2021

The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1.

1 reference

7 January 2021

The ATP-dependent glutathione S-conjugate export pump

1 reference

7 January 2021

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1 reference

7 January 2021

Hepatic canalicular membrane 4: expression of the multidrug resistance genes in the liver.

1 reference

7 January 2021

Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine

1 reference

7 January 2021

Induction of hepatic P-glycoprotein enhances biliary excretion of vincristine in rats

1 reference

7 January 2021

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance

1 reference

7 January 2021

1 reference

7 January 2021

Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity

1 reference

7 January 2021

Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo.

1 reference

7 January 2021

Clinical trials of agents that reverse multidrug resistance. A literature review

1 reference

7 January 2021

Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer

1 reference

7 January 2021

ATP-dependent export pumps and their inhibition by cyclosporins

1 reference

7 January 2021

Modulation by verapamil of vincristine pharmacokinetics and toxicity in mice bearing human tumor xenografts

1 reference

7 January 2021

Effect of modulators of the multidrug resistance pump on the distribution of vinblastine in tissues of the mouse.

1 reference

7 January 2021

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

7 January 2021

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

1 reference

7 January 2021

Multidrug resistance gene family and chemical carcinogens

1 reference

7 January 2021

Ah receptor signaling pathways

1 reference

7 January 2021

Effect of colchicine and heat shock on multidrug resistance gene and P-glycoprotein expression in rat liver.

1 reference

7 January 2021

Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics.

1 reference

7 January 2021

Regulation of 2-acetylaminofluorene-and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver

1 reference

7 January 2021

Regulation of mdr1b gene expression in Fischer, Wistar and Sprague-Dawley rats in vivo and in vitro

1 reference

7 January 2021

Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.

1 reference

7 January 2021

Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis.

1 reference

7 January 2021

Differential modulation of P-glycoprotein transport by protein kinase inhibition.

1 reference

7 January 2021

Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells.

1 reference

7 January 2021

Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells

1 reference

7 January 2021

Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse

1 reference

7 January 2021

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1 reference

7 January 2021

Phosphatidylcholine translocase: a physiological role for the mdr2 gene

1 reference

7 January 2021

MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

1 reference

7 January 2021

Enhancement of Mdr2-mediated phosphatidylcholine translocation by the bile salt taurocholate. Implications for hepatic bile formation

1 reference

7 January 2021

Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics

1 reference

7 January 2021

Secretion of organic anions by hepatocytes: involvement of homologues of the multidrug resistance protein.

1 reference

7 January 2021

Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rat.

1 reference

7 January 2021

Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with a report of 12 cases

1 reference

7 January 2021

Hepatic canalicular membrane. Introduction: transport across the hepatocyte canalicular membrane

1 reference

7 January 2021

Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells.

1 reference

7 January 2021

The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man.

1 reference

7 January 2021

Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia

1 reference

7 January 2021

Biliary excretion of glycyrrhizin in rats: kinetic basis for multiplicity in bile canalicular transport of organic anions

1 reference

7 January 2021

Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinaemic rats

1 reference

7 January 2021

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

1 reference

7 January 2021

cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats

1 reference

7 January 2021

Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver

1 reference

7 January 2021

Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein

1 reference

7 January 2021

Hepatocanalicular organic-anion transport is regulated by protein kinase C

1 reference

7 January 2021

The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis

1 reference

7 January 2021

Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome

1 reference

7 January 2021

Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells)

1 reference

7 January 2021

Evidence for leukotriene C4 transport mediated by an ATP-dependent glutathione S-conjugate carrier in rat heart and liver plasma membranes

1 reference

7 January 2021

Transport of glutathione S‐conjugate from human erythrocytes

1 reference

7 January 2021

Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein

1 reference

7 January 2021

Calcein is excreted from the intestinal mucosal cell membrane by the active transport system

1 reference

7 January 2021

Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics

1 reference

7 January 2021

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

1 reference

7 January 2021

Cellular and in vitro transport of glutathione conjugates by MRP.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1021/BI960098N

Identifiers

DOI

10.1021/JS970100B

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724551%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

1 reference