MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine (Q24317572)

ATP binding cassette subfamily B member 4

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ceramide translocation

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ATP-binding cassette, sub-family B (MDR/TAP), member 1A

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A van Helvoort

1

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A J Smith

2

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H Sprong

3

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I Fritzsche

4

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A H Schinkel

5

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P Borst

6

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G van Meer

Reconstitution of ATP-dependent aminophospholipid translocation in proteoliposomes

7

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language of work or name

English

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publication date

1 November 1996

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published in

Cell

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volume

87

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page(s)

507-17

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issue

3

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cites work

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7 January 2021

Interactions of lyso 1-palmitoylphosphatidylcholine with phospholipids: a 13C and 31P NMR study

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7 January 2021

Topology of sphingolipid galactosyltransferases in ER and Golgi: transbilayer movement of monohexosyl sphingolipids is required for higher glycosphingolipid biosynthesis

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7 January 2021

Ultrafast glycerophospholipid-selective transbilayer motion mediated by a protein in the endoplasmic reticulum membrane

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7 January 2021

Transverse redistribution of phospholipids during human platelet activation: evidence for a vectorial outflux specific to aminophospholipids

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7 January 2021

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies

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7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

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7 January 2021

A Chinese hamster ovary cell mutant defective in the non-endocytic uptake of fluorescent analogs of phosphatidylserine: isolation using a cytosol acidification protocol

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7 January 2021

Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells

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7 January 2021

ABC Transporters: From Microorganisms to Man

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Is the multidrug transporter a flippase?

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7 January 2021

The rate of bulk flow from the Golgi to the plasma membrane

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7 January 2021

Eukaryotic phospholipid biosynthesis

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7 January 2021

Brefeldin A: insights into the control of membrane traffic and organelle structure

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7 January 2021

Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts: endogenously synthesized sphingomyelin and glucocerebroside analogues pass through the Golgi apparatus en route to the plasma membrane

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7 January 2021

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7 January 2021

Lipid traffic in eukaryotic cells: mechanisms for intracellular transport and organelle-specific enrichment of lipids

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7 January 2021

Metabolism and intracellular localization of a fluorescently labeled intermediate in lipid biosynthesis within cultured fibroblasts

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7 January 2021

Molecular arrangements in sphingolipids. Conformation and hydrogen bonding of ceramide and their implication on membrane stability and permeability

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7 January 2021

Phosphatidylcholine translocase: a physiological role for the mdr2 gene

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7 January 2021

Enhancement of Mdr2-mediated phosphatidylcholine translocation by the bile salt taurocholate. Implications for hepatic bile formation

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7 January 2021

Retrograde transport from the Golgi complex to the ER of both Shiga toxin and the nontoxic Shiga B-fragment is regulated by butyric acid and cAMP.

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7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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7 January 2021

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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7 January 2021

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

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7 January 2021

The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

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7 January 2021

Formation of platelet-activating factor-like phospholipids by Fe2+/ascorbate/EDTA-induced lipid peroxidation.

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7 January 2021

A subfamily of P-type ATPases with aminophospholipid transporting activity

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7 January 2021

Lipid transport processes in eukaryotic cells

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7 January 2021

Conversion of alkylacetylglycerol to platelet-activating factor in HL-60 cells and subcellular localization of the mediator

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7 January 2021

Sorting of newly synthesized galactosphingolipids to the two surface domains of epithelial cells

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7 January 2021

Sequence of mdr3 cDNA encoding a human P-glycoprotein

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7 January 2021

Differential targeting of glucosylceramide and galactosylceramide analogues after synthesis but not during transcytosis in Madin-Darby canine kidney cells.

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7 January 2021

Intracellular lipid heterogeneity caused by topology of synthesis and specificity in transport. Example: sphingolipids.

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7 January 2021

Sorting of sphingolipids in epithelial (Madin-Darby canine kidney) cells

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7 January 2021