Synoviolin 1 (Q7395294)

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mammalian protein found in Homo sapiens
  • SYVN1
  • HMG-coA reductase degradation 1 homolog
  • synovial apoptosis inhibitor 1, synoviolin
  • Synovial apoptosis inhibitor 1
  • RING-type E3 ubiquitin transferase synoviolin
  • E3 ubiquitin-protein ligase synoviolin
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Language Label Description Also known as
English
Synoviolin 1
mammalian protein found in Homo sapiens
  • SYVN1
  • HMG-coA reductase degradation 1 homolog
  • synovial apoptosis inhibitor 1, synoviolin
  • Synovial apoptosis inhibitor 1
  • RING-type E3 ubiquitin transferase synoviolin
  • E3 ubiquitin-protein ligase synoviolin

Statements

molecular function
protein binding
determination method
IPI
9 references
retrieved
8 April 2019
stated in
The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins
GOA
curator
UniProt
UniProt protein ID
Q86TM6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IPI
retrieved
8 April 2019
stated in
Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP
GOA
curator
UniProt
UniProt protein ID
Q86TM6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IPI
retrieved
8 April 2019
stated in
Association of the SEL1L protein transmembrane domain with HRD1 ubiquitin ligase regulates ERAD-L
GOA
curator
UniProt
UniProt protein ID
Q86TM6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IPI
retrieved
8 April 2019
stated in
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD
GOA
curator
UniProt
UniProt protein ID
Q86TM6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IPI
retrieved
8 April 2019
stated in
A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IPI
retrieved
8 April 2019
stated in
USP14 inhibits ER-associated degradation via interaction with IRE1alpha
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IPI
retrieved
8 April 2019
stated in
Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IPI
retrieved
8 April 2019
stated in
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IPI
retrieved
8 April 2019
stated in
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IPI
ubiquitin protein ligase activity
determination method
TAS
IEA
IDA
IMP
6 references
retrieved
17 October 2017
stated in
Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
TAS
retrieved
17 October 2017
stated in
HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
IMP
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
IEA
retrieved
17 October 2017
stated in
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
17 October 2017
stated in
Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
17 October 2017
stated in
CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
IDA
ubiquitin protein ligase activity
determination method
IBA
IDA
IEA
IMP
NAS
TAS
11 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
TAS
retrieved
8 April 2019
stated in
Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
TAS
retrieved
8 April 2019
stated in
Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
TAS
retrieved
8 April 2019
stated in
Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
NAS
retrieved
8 April 2019
stated in
HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IEA
retrieved
8 April 2019
stated in
Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
8 April 2019
stated in
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
8 April 2019
stated in
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
8 April 2019
stated in
CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IBA
cell component
endoplasmic reticulum
determination method
TAS
IEA
IDA
6 references
retrieved
8 April 2019
stated in
Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86TM6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IEA
retrieved
8 April 2019
stated in
Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation
GOA
curator
UniProt
UniProt protein ID
Q86TM6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
8 April 2019
stated in
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
8 April 2019
stated in
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IDA
biological process
ubiquitin-dependent ERAD pathway
determination method
TAS
IEA
IDA
IMP
8 references
retrieved
17 October 2017
stated in
Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
TAS
retrieved
17 October 2017
stated in
The unfolded protein response: integrating stress signals through the stress sensor IRE1α
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
TAS
retrieved
17 October 2017
stated in
STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein
GOA
curator
UniProt
UniProt protein ID
Q86TM6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
IMP
retrieved
17 October 2017
stated in
HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
IMP
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
IEA
retrieved
17 October 2017
stated in
Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation
GOA
curator
UniProt
UniProt protein ID
Q86TM6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
17 October 2017
stated in
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
17 October 2017
stated in
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86TM6&geneProductId=UniProtKB:Q86TM6
determination method
IDA
ubiquitin-dependent ERAD pathway
determination method
IBA
IDA
IEA
IMP
TAS
9 references
retrieved
8 April 2019
stated in
Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
TAS
retrieved
8 April 2019
stated in
The unfolded protein response: integrating stress signals through the stress sensor IRE1α
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
TAS
retrieved
8 April 2019
stated in
STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein
GOA
curator
UniProt
UniProt protein ID
Q86TM6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IMP
retrieved
8 April 2019
stated in
HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IEA
retrieved
8 April 2019
stated in
Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation
GOA
curator
UniProt
UniProt protein ID
Q86TM6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
8 April 2019
stated in
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
8 April 2019
stated in
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86TM6
determination method
IBA
EC enzyme number
6.3.2.-
0 references
HomoloGene ID
32700
0 references

Identifiers

OMIM ID
608046
0 references
 
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