Signal transducer and activator of transcription 1 (Q7394687)

STAT transcription factor, DNA-binding, N-terminal

1 reference

transcription factor STAT

1 reference

STAT transcription factor, coiled coil

1 reference

SH2 domain superfamily

1 reference

STAT transcription factor, N-terminal domain superfamily

1 reference

STAT1, C-terminal domain superfamily

1 reference

STAT transcription factor, protein interaction, protein family

1 reference

STAT1, SH2 domain, protein family

1 reference

SH2 domain, protein family

1 reference

STAT transcription factor, DNA-binding domain, protein family

1 reference

Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal domain, protein family

1 reference

STAT transcription factor, all-alpha domain, protein family

1 reference

DNA-binding transcription factor activity

1 reference

13 November 2019

1 reference

13 November 2019

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

RNA polymerase II general transcription initiation factor activity

1 reference

27 March 2018

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224

signal transducer activity

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224

RNA polymerase II cis-regulatory region sequence-specific DNA binding

2 references

36 references

9 May 2019

Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Structural bases of unphosphorylated STAT1 association and receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

A quantitative protein interaction network for the ErbB receptors using protein microarrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

VP8, the Major Tegument Protein of Bovine Herpesvirus 1, Interacts with Cellular STAT1 and Inhibits Interferon Beta Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

PIPINO: A Software Package to Facilitate the Identification of Protein-Protein Interactions from Affinity Purification Mass Spectrometry Data

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Hepatitis C virus expression suppresses interferon signaling by degrading STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

A comprehensive resource of interacting protein regions for refining human transcription factor networks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Direct suppression of Stat1 function during adenoviral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Acetylation-dependent signal transduction for type I interferon receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

VP8, the Major Tegument Protein of Bovine Herpesvirus 1, Interacts with Cellular STAT1 and Inhibits Interferon Beta Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Hepatitis C virus expression suppresses interferon signaling by degrading STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

2 references

tumor necrosis factor receptor binding

1 reference

9 May 2019

Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

double-stranded DNA binding

IPI

1 reference

9 May 2019

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

1 reference

27 March 2018

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224

histone acetyltransferase binding

1 reference

9 May 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

1 reference

9 May 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

ubiquitin-like protein ligase binding

IPI

1 reference

9 May 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

promoter-specific chromatin binding

IPI

1 reference

9 May 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

sequence-specific DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

27 March 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224

27 March 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224

27 March 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224

transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding

ISA

1 reference

27 March 2018

Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224

DNA-binding transcription factor activity, RNA polymerase II-specific

4 references

9 May 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

CCR5 chemokine receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

1 reference

9 May 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

protein phosphatase 2A binding

HDA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 references

9 May 2019

Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

10 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Hepatitis C virus expression suppresses interferon signaling by degrading STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

perinuclear region of cytoplasm

1 reference

9 May 2019

HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

11 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

8 April 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

8 April 2019

hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

8 April 2019

Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

8 April 2019

Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

8 April 2019

Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

8 April 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

8 April 2019

Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

8 April 2019

Hepatitis C virus expression suppresses interferon signaling by degrading STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

protein-containing complex

1 reference

9 May 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

12 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Hepatitis C virus expression suppresses interferon signaling by degrading STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

regulation of apoptotic process

1 reference

9 May 2019

The role of STATs in apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

metanephric mesenchymal cell proliferation involved in metanephros development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

cellular response to interferon-beta

1 reference

9 May 2019

Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

regulation of transcription by RNA polymerase II

1 reference

27 March 2018

Cooperation among Stat1, glucocorticoid receptor, and PU.1 in transcriptional activation of the high-affinity Fc gamma receptor I in monocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224

negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

metanephric mesenchymal cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

tumor necrosis factor-mediated signaling pathway

1 reference

9 May 2019

Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

negative regulation of transcription by RNA polymerase II

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

STAT1 is required for redifferentiation during Madin-Darby canine kidney tubulogenesis

renal tubule development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

response to interferon-beta

1 reference

9 May 2019

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

negative regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

9 May 2019

Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224

negative regulation of endothelial cell proliferation

1 reference

9 May 2019

Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

regulation of type I interferon-mediated signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224

regulation of interferon-gamma-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

positive regulation of mesenchymal cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

negative regulation of metanephric nephron tubule epithelial cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

negative regulation of angiogenesis

1 reference

9 May 2019

Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

negative regulation by virus of viral protein levels in host cell

1 reference

9 May 2019

Hepatitis C virus expression suppresses interferon signaling by degrading STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

endothelial cell migration

1 reference

9 May 2019

Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

positive regulation of transcription by RNA polymerase II

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

macrophage derived foam cell differentiation

1 reference

9 May 2019

Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

positive regulation of erythrocyte differentiation

1 reference

9 May 2019

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

type I interferon signaling pathway

cellular response to interferon-gamma

1 reference

9 May 2019

hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

positive regulation of defense response to virus by host

IGI

positive regulation of interferon-alpha production

1 reference

9 May 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

positive regulation of transcription, DNA-templated

3 references

9 May 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

interferon-gamma-mediated signaling pathway

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

positive regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

response to mechanical stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

response to organic cyclic compound

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

cellular response to insulin stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

response to hydrogen peroxide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

positive regulation of nitric-oxide synthase biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

cellular response to cytokine stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

cellular response to organic cyclic compound

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

positive regulation of transcription of Notch receptor target

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

cytokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

interleukin-21-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

interleukin-6-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

interleukin-27-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

interleukin-35-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

interleukin-9-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

receptor signaling pathway via JAK-STAT

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

regulation of cell population proliferation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

response to peptide hormone

3 references

positive regulation of transcription by RNA polymerase II

type I interferon signaling pathway

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224

Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal

Gene Atlas image

PBB GE STAT1 200887 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

1 reference

SH2 domain

1 reference

STAT transcription factor, all-alpha domain

1 reference

STAT transcription factor, DNA-binding

1 reference

STAT transcription factor, protein interaction

1 reference

STAT1, SH2 domain

1 reference

Identifiers

0 references

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference