mitogen-activated protein kinase 1 (Q6590503)

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mammalian protein found in Homo sapiens
  • MAP kinase isoform p42
  • ERT1
  • extracellular signal-regulated kinase 2
  • p42-MAPK
  • mitogen-activated protein kinase 2
  • MAPK1
  • MAP kinase 2
  • ERK-2
  • protein tyrosine kinase ERK2
  • MAP kinase 1
  • MAPK 2
edit
Language Label Description Also known as
English
mitogen-activated protein kinase 1
mammalian protein found in Homo sapiens
  • MAP kinase isoform p42
  • ERT1
  • extracellular signal-regulated kinase 2
  • p42-MAPK
  • mitogen-activated protein kinase 2
  • MAPK1
  • MAP kinase 2
  • ERK-2
  • protein tyrosine kinase ERK2
  • MAP kinase 1
  • MAPK 2

Statements

molecular function
protein binding
determination method
IPI
32 references
retrieved
8 April 2019
stated in
The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
MFAP3L activation promotes colorectal cancer cell invasion and metastasis
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Mxi2 promotes stimulus-independent ERK nuclear translocation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Functional specialization of beta-arrestin interactions revealed by proteomic analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of U24 from Human Herpes Virus type 6 (HHV-6) and its potential role in mimicking myelin basic protein (MBP) in multiple sclerosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IPI
protein serine/threonine kinase activity
determination method
IEA
IDA
TAS
6 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28482&geneProductId=UniProtKB:P28482
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28482&geneProductId=UniProtKB:P28482
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28482&geneProductId=UniProtKB:P28482
determination method
IEA
retrieved
1 January 2018
stated in
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28482&geneProductId=UniProtKB:P28482
determination method
IDA
retrieved
1 January 2018
stated in
The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28482&geneProductId=UniProtKB:P28482
determination method
IDA
retrieved
1 January 2018
stated in
Regulation of Microtubule Assembly by Tau and not by Pin1.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P28482&geneProductId=UniProtKB:P28482
determination method
IDA
cell component
nucleus
determination method
HDA
IBA
IDA
IEA
TAS
6 references
retrieved
8 April 2019
stated in
The ERK signaling cascade--views from different subcellular compartments
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IEA
retrieved
8 April 2019
stated in
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IBA
retrieved
8 April 2019
stated in
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
HDA
cytoplasm
determination method
HDA
IBA
IDA
IEA
ISS
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IEA
retrieved
8 April 2019
stated in
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
IBA
retrieved
8 April 2019
stated in
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins
GOA
curator
UniProt
UniProt protein ID
P28482
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28482
determination method
HDA
biological process

Identifiers

MeSH descriptor ID
D019950
subject named as
Mitogen-Activated Protein Kinase 1
0 references
PDB structure ID
 
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