A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death (Q64278443)

NAD+ nucleotidase, cyclic ADP-ribose generating

GOA release 2020-03-11

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GOA release 2020-03-11

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Zhi Ying Zhao

1

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Xu Jie Xie

2

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Wan Hua Li

3

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Jun Liu

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Zhe Chen

5

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Ben Zhang

6

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Ting Li

7

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Song Lu Li

8

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Jun Gang Lu

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Liangren Zhang

10

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Li-He Zhang

11

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Zhengshuang Xu

12

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Hon Cheung Lee

13

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Yong Juan Zhao

Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose

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language of work or name

English

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publication date

31 May 2019

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volume

15

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page(s)

452-466

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cites work

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12 December 2020

Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation

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12 December 2020

Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity

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12 December 2020

Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate

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12 December 2020

The crystal structure of cyclic ADP-ribose

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12 December 2020

ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1

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12 December 2020

A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose

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12 December 2020

Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.

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12 December 2020

A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes

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12 December 2020

Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release.

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12 December 2020

Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose

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12 December 2020

ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP

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12 December 2020

Fluorescent analogs of cyclic ADP-ribose: synthesis, spectral characterization, and use

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12 December 2020

A single residue at the active site of CD38 determines its NAD cyclizing and hydrolyzing activities

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12 December 2020

Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo

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12 December 2020

A novel cycling assay for cellular cADP-ribose with nanomolar sensitivity

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12 December 2020

Crystal structure of human CD38 extracellular domain

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12 December 2020

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

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12 December 2020

Structure and enzymatic functions of human CD38.

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12 December 2020

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology

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12 December 2020

Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38

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12 December 2020

Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium (dagger) (double dagger)

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12 December 2020

NAADP mobilizes calcium from acidic organelles through two-pore channels

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12 December 2020

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

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12 December 2020

Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase

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12 December 2020

Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal

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12 December 2020

Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

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12 December 2020

Cytosolic CD38 protein forms intact disulfides and is active in elevating intracellular cyclic ADP-ribose

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12 December 2020

Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology

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12 December 2020

The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism

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12 December 2020

TAL effectors: customizable proteins for DNA targeting

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12 December 2020

Catalysis-based inhibitors of the calcium signaling function of CD38

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12 December 2020

Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence

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12 December 2020

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

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12 December 2020

The membrane-bound enzyme CD38 exists in two opposing orientations

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12 December 2020

T-cell death following immune activation is mediated by mitochondria-localized SARM.

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12 December 2020

Sarm1-mediated axon degeneration requires both SAM and TIR interactions

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12 December 2020

Genome engineering using the CRISPR-Cas9 system

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12 December 2020

Targeted, LCMS-based Metabolomics for Quantitative Measurement of NAD(+) Metabolites

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12 December 2020

Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons

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12 December 2020

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

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12 December 2020

Determinants of the membrane orientation of a calcium signaling enzyme CD38

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12 December 2020

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

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12 December 2020

SARM1 activation triggers axon degeneration locally via NAD⁺ destruction

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12 December 2020

Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38

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12 December 2020

Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca(2+) Influx but Only Modestly Influenced by Mitochondria.

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12 December 2020

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

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12 December 2020

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation

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12 December 2020

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

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12 December 2020

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

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12 December 2020

Evaluation of Nanobody Conjugates and Protein Fusions as Bioanalytical Reagents.

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12 December 2020

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.

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12 December 2020

Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels.

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12 December 2020

TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.

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12 December 2020

JNK-mediated phosphorylation of SARM1 regulates NAD cleavage activity to inhibit mitochondrial respiration

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12 December 2020

Slc12a8 is a nicotinamide mononucleotide transporter

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12 December 2020