JNK-mediated phosphorylation of SARM1 regulates NAD cleavage activity to inhibit mitochondrial respiration (Q58544845)

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29 April 2020

title

c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration (English)

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29 April 2020

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Hitoshi Murata

1

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29 April 2020

Cho Cho Khine

2

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29 April 2020

Akane Nishikawa

3

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Ken-Ichi Yamamoto

4

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Rie Kinoshita

5

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Masakiyo Sakaguchi

6

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language of work or name

English

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publication date

17 October 2018

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Journal of Biological Chemistry

29 April 2020

published in

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volume

293

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issue

49

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page(s)

18933-18943

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Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

29 April 2020

cites work

1 reference

12 December 2020

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival

1 reference

12 December 2020

Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

1 reference

12 December 2020

Axonal degeneration in multiple sclerosis: the mitochondrial hypothesis

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12 December 2020

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

1 reference

12 December 2020

SARM inhibits both TRIF- and MyD88-mediated AP-1 activation.

1 reference

12 December 2020

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

1 reference

12 December 2020

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

1 reference

12 December 2020

A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2

1 reference

12 December 2020

Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1.

1 reference

12 December 2020

Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence

1 reference

12 December 2020

Discovery of Potent and Selective Covalent Inhibitors of JNK

1 reference

12 December 2020

Axon degeneration in Parkinson's disease

1 reference

12 December 2020

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

1 reference

12 December 2020

Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system.

1 reference

12 December 2020

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

1 reference

12 December 2020

T-cell death following immune activation is mediated by mitochondria-localized SARM.

1 reference

12 December 2020

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

1 reference

12 December 2020

Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death

1 reference

12 December 2020

SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria

1 reference

12 December 2020

Sarm1-mediated axon degeneration requires both SAM and TIR interactions

1 reference

12 December 2020

Dramatic increase in expression of a transgene by insertion of promoters downstream of the cargo gene.

1 reference

12 December 2020

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

1 reference

12 December 2020

Ubiquitin is phosphorylated by PINK1 to activate parkin

1 reference

12 December 2020

Wallerian degeneration: an emerging axon death pathway linking injury and disease

1 reference

12 December 2020

Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons

1 reference

12 December 2020

Pathological axonal death through a MAPK cascade that triggers a local energy deficit

1 reference

12 December 2020

Absence of SARM1 rescues development and survival of NMNAT2-deficient axons

1 reference

12 December 2020

SARM1 activation triggers axon degeneration locally via NAD⁺ destruction

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12 December 2020

Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons.

1 reference

12 December 2020

SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons

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12 December 2020

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

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12 December 2020

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1.

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12 December 2020

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

1 reference

12 December 2020

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation

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12 December 2020

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.

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12 December 2020

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.

1 reference

12 December 2020

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.

1 reference

12 December 2020

Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy

1 reference

12 December 2020

Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

1 reference

12 December 2020

The genetics of Parkinson disease

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.RA118.004578

1 reference

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PubMed publication ID

30333228

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