PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma (Q64052630)

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27 April 2020

title

PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma (English)

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27 April 2020

main subject

sorafenib

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hepatocellular carcinoma

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13

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27 April 2020

5

Qiang Yu

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27 April 2020

4

Kan Chen

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27 April 2020

10

Weiqi Dai

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27 April 2020

author name string

Jiao Feng

1

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27 April 2020

Liwei Wu

2

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27 April 2020

Jie Ji

3

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27 April 2020

Jie Zhang

6

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27 April 2020

Jiaojiao Chen

7

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27 April 2020

Yuqing Mao

8

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27 April 2020

Fan Wang

9

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27 April 2020

Ling Xu

11

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27 April 2020

Jianye Wu

12

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27 April 2020

language of work or name

English

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publication date

17 May 2019

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Journal of Experimental & Clinical Cancer Research

27 April 2020

published in

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volume

38

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27 April 2020

page(s)

204

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issue

1

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Hepatocellular carcinoma: epidemiology and molecular carcinogenesis

27 April 2020

cites work

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12 December 2020

Multi-targeted prevention and therapy of cancer by proanthocyanidins

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12 December 2020

Molecular mechanisms of hepatocellular carcinoma

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12 December 2020

Role of hypoxia-inducible transcription factor 1alpha for progression and chemosensitivity of murine hepatocellular carcinoma

1 reference

12 December 2020

Targeting the dynamic HSP90 complex in cancer

1 reference

12 December 2020

Hallmarks of Cancer: The Next Generation

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12 December 2020

Effect of sorafenib on the energy metabolism of hepatocellular carcinoma cells

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12 December 2020

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

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12 December 2020

Hepatocellular carcinoma

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12 December 2020

Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death

1 reference

12 December 2020

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

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12 December 2020

Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma

1 reference

12 December 2020

Effect of grape procyanidins on tumor angiogenesis in liver cancer xenograft models.

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12 December 2020

Procyanidin B2 inhibits inflammasome-mediated IL-1β production in lipopolysaccharide-stimulated macrophages.

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12 December 2020

Hypoxia-inducible factor-1alpha in hepatic fibrosis: A promising therapeutic target

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12 December 2020

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12 December 2020

Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis

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12 December 2020

Procyanidin B2 3,3″-di-O-gallate inhibits endothelial cells growth and motility by targeting VEGFR2 and integrin signaling pathways

1 reference

12 December 2020

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages

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12 December 2020

Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture

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12 December 2020

The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing.

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12 December 2020

Protective Effect of Procyanidin B2 against CCl4-Induced Acute Liver Injury in Mice.

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12 December 2020

HSP90 inhibits apoptosis and promotes growth by regulating HIF-1α abundance in hepatocellular carcinoma

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12 December 2020

Procyanidins from Nelumbo nucifera Gaertn. Seedpod induce autophagy mediated by reactive oxygen species generation in human hepatoma G2 cells

1 reference

12 December 2020

MiR-122 Reverses the Doxorubicin-Resistance in Hepatocellular Carcinoma Cells through Regulating the Tumor Metabolism

1 reference

12 December 2020

Over expression of hyaluronan promotes progression of HCC via CD44-mediated pyruvate kinase M2 nuclear translocation

1 reference

12 December 2020

Comparison of Outcome of Hepatic Arterial Infusion Chemotherapy and Sorafenib in Patients with Hepatocellular Carcinoma Refractory to Transcatheter Arterial Chemoembolization

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12 December 2020

The role of heat shock proteins and glucose regulated proteins in cancer.

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12 December 2020

PKM2, cancer metabolism, and the road ahead

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12 December 2020

Nuclear PKM2 expression, an independent risk factor for ER after curative resection of hepatocellular carcinoma.

1 reference

12 December 2020

Grape seed procyanidin B2 inhibits adipogenesis of 3T3-L1 cells by targeting peroxisome proliferator-activated receptor γ with miR-483-5p involved mechanism

1 reference

12 December 2020

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis.

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12 December 2020

Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression

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12 December 2020

By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma.

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12 December 2020

Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death.

1 reference

12 December 2020

Plasma Heat Shock Protein 90alpha as a Biomarker for the Diagnosis of Liver Cancer: An Official, Large-scale, and Multicenter Clinical Trial

1 reference

12 December 2020

Epidemiology of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.

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12 December 2020

Plasma HSP90α and liver cancer: a potential biomarker?

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12 December 2020

Cancer Chemopreventive Potential of Procyanidin

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12 December 2020

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.

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12 December 2020

Role of PKM2 in directing the metabolic fate of glucose in cancer: a potential therapeutic target.

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12 December 2020

Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.

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12 December 2020

Tyrosine Kinase Signaling in Cancer Metabolism: PKM2 Paradox in the Warburg Effect

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12 December 2020

Targeting mitochondria in cancer: current concepts and immunotherapy approaches

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12 December 2020

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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12 December 2020

Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation

1 reference

12 December 2020

Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors

1 reference

12 December 2020

Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma

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12 December 2020

Gankyrin drives metabolic reprogramming to promote tumorigenesis, metastasis and drug resistance through activating β-catenin/c-Myc signaling in human hepatocellular carcinoma

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12 December 2020

10.1186/S13046-019-1194-Z

Identifiers

DOI

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27 April 2020

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