By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma. (Q47878727)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28857200%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

title

By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma (English)

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1

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Chuanyong Guo

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Qiang Yu

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Yingqun Zhou

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author name string

Weiqi Dai

2

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Wenhui Mo

3

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Jingjing Li

4

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Jiao Feng

5

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Liwei Wu

6

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Tong Liu

7

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Shizan Xu

9

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Wenwen Wang

10

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Xiya Lu

11

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Qinghui Zhang

12

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Kan Chen

13

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Yujing Xia

14

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Jie Lu

15

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Xiaoming Fan

17

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Ling Xu

18

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language of work or name

English

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publication date

14 September 2017

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International Journal of Cancer

28 March 2020

published in

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volume

141

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issue

12

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page(s)

2571-2584

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28 March 2020

cites work

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Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma.

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21 January 2018

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Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial

21 January 2018

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PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation

21 January 2018

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Otto Warburg's contributions to current concepts of cancer metabolism

21 January 2018

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Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism

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Modulation of glycolysis and lipogenesis by novel PI3K selective molecule represses tumor angiogenesis and decreases colorectal cancer growth.

21 January 2018

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Carboxyamidotriazole inhibits oxidative phosphorylation in cancer cells and exerts synergistic anti-cancer effect with glycolysis inhibition

21 January 2018

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Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

21 January 2018

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Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma

21 January 2018

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Blocking preferential glucose uptake sensitizes liver tumor-initiating cells to glucose restriction and sorafenib treatment.

21 January 2018

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Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer

21 January 2018

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Anti-inflammatory Agents: Present and Future

21 January 2018

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Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

21 January 2018

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Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials.

21 January 2018

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Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma

21 January 2018

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Aspirin use and survival after diagnosis of colorectal cancer

21 January 2018

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The ancient drug salicylate directly activates AMP-activated protein kinase

21 January 2018

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The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer

21 January 2018

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Acetylsalicylic acid and salicylic acid decrease tumor cell viability and glucose metabolism modulating 6-phosphofructo-1-kinase structure and activity

21 January 2018

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Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

21 January 2018

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By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice.

21 January 2018

1 reference

In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity.

21 January 2018

1 reference

QSG-7701 human hepatocytes form polarized acini in three-dimensional culture

21 January 2018

1 reference

Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells

21 January 2018

1 reference

Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.

21 January 2018

1 reference

Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway

21 January 2018

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Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD.

21 January 2018

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21 January 2018

Mitochondria and Cancer

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21 January 2018

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Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release

21 January 2018

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Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1.

21 January 2018

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21 January 2018

Hepatocellular carcinoma

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Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3.

21 January 2018

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Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: partial mediation by the transcription factor NFAT1.

21 January 2018

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Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Κb P65 and Wnt/Β-Catenin in Vitro.

21 January 2018

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Focal gains of VEGFA: candidate predictors of sorafenib response in hepatocellular carcinoma.

21 January 2018

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Nitric oxide-donating aspirin inhibits the growth of pancreatic cancer cells through redox-dependent signaling

21 January 2018

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Pharmacoepidemiology of Clinically Relevant Hypothyroidism and Hypertension from Sunitinib and Sorafenib

21 January 2018

1 reference

Economic evaluation of sorafenib in unresectable hepatocellular carcinoma

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IJC.31022

1 reference

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28 March 2020

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