The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention? (Q63101708)

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The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention? (English)

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Are tangles as toxic as they look?

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Towards a Pharmacophore for Amyloid

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New insights into tau-microtubules interaction revealed by isothermal titration calorimetry

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Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease

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A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge

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The Cerebrospinal Fluid Neurogranin/BACE1 Ratio is a Potential Correlate of Cognitive Decline in Alzheimer's Disease

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Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells.

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Propagation of Tau aggregates

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Neurotoxicity of Zinc.

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Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking.

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Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

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Atypical, non-standard functions of the microtubule associated Tau protein

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The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases.

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Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

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Is longitudinal tau PET ready for use in Alzheimer's disease clinical trials?

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Amyloidogenic cross-seeding of Tau protein: Transient emergence of structural variants of fibrils

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Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT)

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Structures of filaments from Pick's disease reveal a novel tau protein fold

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12 December 2020

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease

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12 December 2020

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Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms

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Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold

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12 December 2020

Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody

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Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions

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Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

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Direct Crosstalk Between -GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy

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Different tau species lead to heterogeneous tau pathology propagation and misfolding

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Correlation of In Vivo [18F]Flortaucipir With Postmortem Alzheimer Disease Tau Pathology

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Biomarkers for tau pathology.

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Cofactors are essential constituents of stable and seeding-active tau fibrils

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Zinc Induces Temperature-Dependent Reversible Self-Assembly of Tau

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Longitudinal tau accumulation and atrophy in aging and alzheimer disease

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Functional Status of Neuronal Calcium Sensor-1 Is Modulated by Zinc Binding

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12 December 2020

Role of tau N-terminal motif in the secretion of human tau by End Binding proteins

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Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases

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Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.

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A walk through tau therapeutic strategies

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12 December 2020

10.1186/S40478-019-0682-X

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