Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo (Q59098643)

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Arkady Celeste

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Simone Difilippantonio

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Rong Guo

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Weidong Wang

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Lionel Feigenbaum

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André Nussenzweig

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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publication date

13 August 2006

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language of work or name

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443

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issue

7108

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page(s)

222-225

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cites work

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

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A simple two-step, 'hit and fix' method to generate subtle mutations in BACs using short denatured PCR fragments

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ATM activation in normal human tissues and testicular cancer

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Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

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Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

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Checking on DNA damage in S phase

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation

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Requirement of the MRN complex for ATM activation by DNA damage

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

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Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

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Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

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Mre11 assembles linear DNA fragments into DNA damage signaling complexes

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

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A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

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Involvement of human MOF in ATM function

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Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

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Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex

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Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity

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Active role for nibrin in the kinetics of atm activation

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Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

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