The saintly side of Smac/DIABLO: giving anticancer drug-induced apoptosis a boost (Q58289658)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14502234%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

title

The saintly side of Smac/DIABLO: giving anticancer drug-induced apoptosis a boost (English)

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19 December 2019

2

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19 December 2019

author name string

C R Arnt

series ordinal

1

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19 December 2019

publication date

1 October 2003

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Cell Death & Differentiation

19 December 2019

published in

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19 December 2019

volume

10

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19 December 2019

issue

10

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19 December 2019

page(s)

1118-1120

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From bench to clinic with apoptosis-based therapeutic agents

19 December 2019

cites work

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Mitochondria: releasing power for life and unleashing the machineries of death

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Caspase-9 and APAF-1 form an active holoenzyme

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

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DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9

21 January 2018

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Structural basis of IAP recognition by Smac/DIABLO

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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Structural and biochemical basis of apoptotic activation by Smac/DIABLO

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A single BIR domain of XIAP sufficient for inhibiting caspases

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Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis

21 January 2018

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Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release

21 January 2018

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Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

21 January 2018

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Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

21 January 2018

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Role of Smac in human leukaemic cell apoptosis and proliferation

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Destabilizing influences in apoptosis: sowing the seeds of IAP destruction

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Characterization of XIAP-deficient mice

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Generation and characterization of Smac/DIABLO-deficient mice.

21 January 2018

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A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO

21 January 2018

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A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.

21 January 2018

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Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

21 January 2018

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Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis

21 January 2018

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Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells

21 January 2018

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Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

21 January 2018

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SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)

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inferred from DOI database lookup

7 January 2021

based on heuristic

The kinetics of translocation of Smac/DIABLO from the mitochondria to the cytosol in HeLa cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401294