Furin, paired basic amino acid cleaving enzyme (Q581324)

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mammalian protein found in Homo sapiens
  • FURIN/ADAMTS1 fusion
  • dibasic processing enzyme
  • proprotein convertase subtilisin/kexin type 3
  • FES upstream region
  • furin, membrane associated receptor protein
  • Dibasic-processing enzyme
  • FURIN
  • paired basic amino acid residue-cleaving enzyme
  • PACE
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Language Label Description Also known as
English
Furin, paired basic amino acid cleaving enzyme
mammalian protein found in Homo sapiens
  • FURIN/ADAMTS1 fusion
  • dibasic processing enzyme
  • proprotein convertase subtilisin/kexin type 3
  • FES upstream region
  • furin, membrane associated receptor protein
  • Dibasic-processing enzyme
  • FURIN
  • paired basic amino acid residue-cleaving enzyme
  • PACE

Statements

part of
molecular function
serine-type endopeptidase activity
determination method
IDA
IEA
IMP
TAS
6 references
retrieved
26 September 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
TAS
retrieved
26 September 2017
stated in
Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage
GOA
curator
UniProt
UniProt protein ID
P09958
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IMP
retrieved
26 September 2017
stated in
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation
GOA
curator
UniProt
UniProt protein ID
P09958
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IMP
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IEA
retrieved
26 September 2017
stated in
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
26 September 2017
stated in
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IDA
serine-type endopeptidase activity
determination method
IBA
IDA
IEA
IMP
TAS
8 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
TAS
retrieved
8 April 2019
stated in
Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage
GOA
curator
UniProt
UniProt protein ID
P09958
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IMP
retrieved
8 April 2019
stated in
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation
GOA
curator
UniProt
UniProt protein ID
P09958
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IEA
retrieved
8 April 2019
stated in
Processing of transforming growth factor beta 1 precursor by human furin convertase
GOA
curator
UniProt
UniProt protein ID
P09958
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
8 April 2019
stated in
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
8 April 2019
stated in
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IBA
cell component
biological process
protein processing
determination method
IDA
IEA
IMP
8 references
retrieved
26 September 2017
stated in
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IMP
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IEA
retrieved
26 September 2017
stated in
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
GOA
curator
UniProt
UniProt protein ID
P09958
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
26 September 2017
stated in
Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
26 September 2017
stated in
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
26 September 2017
stated in
Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
26 September 2017
stated in
Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
26 September 2017
stated in
Processing of prothyrotropin-releasing hormone by the family of prohormone convertases
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958
determination method
IDA
protein processing
determination method
IBA
IDA
IEA
IMP
9 references
retrieved
8 April 2019
stated in
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IEA
retrieved
8 April 2019
stated in
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
GOA
curator
UniProt
UniProt protein ID
P09958
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
8 April 2019
stated in
Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
8 April 2019
stated in
Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
8 April 2019
stated in
Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
8 April 2019
stated in
Processing of prothyrotropin-releasing hormone by the family of prohormone convertases
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
8 April 2019
stated in
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958
determination method
IBA
Gene Atlas image
PBB GE FURIN 201945 at fs.png
732 × 530; 12 KB
0 references

Identifiers

 
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