Processing of prothyrotropin-releasing hormone by the family of prohormone convertases (Q24320347)

Furin, paired basic amino acid cleaving enzyme

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peptide hormone processing

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Proprotein convertase subtilisin/kexin type 1

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Proprotein convertase subtilisin/kexin type 5

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Proprotein convertase subtilisin/kexin type 2

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author name string

P Schaner

1

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R B Todd

2

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N G Seidah

3

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E A Nillni

Journal of Biological Chemistry

4

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language of work or name

English

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publication date

8 August 1997

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published in

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volume

272

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page(s)

19958-68

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issue

32

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cites work

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions

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Identification of the thyrotropin-releasing hormone-prohormone and its posttranslational processing in a transfected AtT20 tumoral cell line

21 January 2018

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Thyrotropin-releasing hormone precursor: characterization in rat brain

21 January 2018

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The biosynthesis of neuropeptides: peptide alpha-amidation

21 January 2018

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Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary

21 January 2018

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Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes

21 January 2018

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Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

21 January 2018

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Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.

21 January 2018

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Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans

21 January 2018

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cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases

21 January 2018

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Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase

21 January 2018

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Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

21 January 2018

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cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

21 January 2018

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Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4

21 January 2018

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Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease.

21 January 2018

1 reference

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cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases

21 January 2018

1 reference

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PC8 [corrected], a new member of the convertase family

21 January 2018

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SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.

21 January 2018

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Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3

21 January 2018

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Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases.

21 January 2018

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Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways

21 January 2018

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PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues

21 January 2018

1 reference

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Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes

21 January 2018

1 reference

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Processing of secretogranin II by prohormone convertases: importance of PC1 in generation of secretoneurin

21 January 2018

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Cloning and Functional Expression of a Novel Endoprotease Involved in Prohormone Processing at Dibasic Sites1

21 January 2018

1 reference

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7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity

21 January 2018

1 reference

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7B2 is a specific intracellular binding protein of the prohormone convertase PC2

21 January 2018

1 reference

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A prepro-TRH connecting peptide (prepro-TRH 160-169) potentiates TRH-induced TSH release from rat perifused pituitaries by stimulating dihydropyridine- and omega-conotoxin-sensitive Ca2+ channels.

21 January 2018

1 reference

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Preprothyrotropin-releasing hormone-(178-199) does not inhibit corticotropin release

21 January 2018

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Immunocytochemical distribution in rat brain of putative peptides derived from thyrotropin-releasing hormone prohormone.

21 January 2018

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Localization of thyrotropin-releasing hormone prohormone messenger ribonucleic acid in rat brain in situ hybridization

21 January 2018

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Differential coexpression of genes encoding prothyrotropin-releasing hormone (pro-TRH) and prohormone convertases (PC1 and PC2) in rat brain neurons: implications for differential processing of pro-TRH.

21 January 2018

1 reference

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TRH-extended peptides in the olfactory lobe are formed by incomplete cleavage at pairs of arginine residues in the TRH prohormone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.19958

Processing of thyrotropin-releasing hormone (TRH) prohormone in the rat olfactory bulb generates novel TRH-related peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.19958

Pro-protein convertases of subtilisin/kexin family.

21 January 2018

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21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.19958

Differences in pH optima and calcium requirements for maturation of the prohormone convertases PC2 and PC3 indicates different intracellular locations for these events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.19958

Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA.

21 January 2018

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Prolactin and thyrotropin release in man by synthetic pyroglutamyl-histidyl-prolinamide

21 January 2018

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7 January 2021

TRH: a possible mediator of thermoregulation

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https://api.crossref.org/works/10.1074%2FJBC.272.32.19958

7 January 2021

Pro-thyrotropin-releasing hormone processing by recombinant PC1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.19958

7 January 2021

Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor

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https://api.crossref.org/works/10.1074%2FJBC.272.32.19958

7 January 2021

Intracellular sites of prothyrotropin-releasing hormone processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.19958

7 January 2021

Proteases and the emerging role of protease inhibitors in prohormone processing.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.19958

7 January 2021

Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.19958

7 January 2021

In vitro studies on mechanism of action of thyrotropin releasing factor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.19958

7 January 2021