Efflux Pumps in Mycobacteria: Antimicrobial Resistance, Physiological Functions, and Role in Pathogenicity (Q57656351)

1

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Diana Machado

2

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Daniela Ramos

3

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Isabel Couto

4

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Andrea Von Groll

5

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Miguel Viveiros

Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria

6

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publication date

2016

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page(s)

527-559

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cites work

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The role of efflux pumps in macrolide resistance in Mycobacterium avium complex

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Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis

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The importance of efflux pumps in bacterial antibiotic resistance

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Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria

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Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis

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Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpA

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Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis

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Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis

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Study of the rifampin monoresistance mechanism in Mycobacterium tuberculosis

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Rv1218c, an ABC transporter of Mycobacterium tuberculosis with implications in drug discovery

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The expression of ABC efflux pump, Rv1217c-Rv1218c, and its association with multidrug resistance of Mycobacterium tuberculosis in China

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Involvement of efflux pumps in the resistance to peptidoglycan synthesis inhibitors in Mycobacterium tuberculosis

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BacA, an ABC transporter involved in maintenance of chronic murine infections with Mycobacterium tuberculosis

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Assessment of efflux pump gene expression in a clinical isolate Mycobacterium tuberculosis by real-time reverse transcription PCR.

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An attenuated mutant of the Rv1747 ATP-binding cassette transporter of Mycobacterium tuberculosis and a mutant of its cognate kinase, PknF, show increased expression of the efflux pump-related iniBAC operon

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A Mycobacterium tuberculosis gene cluster encoding proteins of a phosphate transporter homologous to the Escherichia coli Pst system.

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Efflux pumps of Mycobacterium tuberculosis play a significant role in antituberculosis activity of potential drug candidates

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Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth

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Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis

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MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

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The mycobacterial P55 efflux pump is required for optimal growth on cholesterol

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Isoniazid resistance without a loss of fitness in Mycobacterium tuberculosis.

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The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV).

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WhiB7, a transcriptional activator that coordinates physiology with intrinsic drug resistance in Mycobacterium tuberculosis.

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Ancestral antibiotic resistance in Mycobacterium tuberculosis

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Gene expression of Mycobacterium tuberculosis putative transcription factors whiB1-7 in redox environments.

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Aminoglycoside cross-resistance in Mycobacterium tuberculosis due to mutations in the 5' untranslated region of whiB7.

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Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis

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Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex

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TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification

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Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG.

21 January 2018

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Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs

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LfrR is a repressor that regulates expression of the efflux pump LfrA in Mycobacterium smegmatis

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Structural Plasticity and Distinct Drug-Binding Modes of LfrR, a Mycobacterial Efflux Pump Regulator

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Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions

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Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria

21 January 2018

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Crystal structure of the transcriptional regulator Rv1219c ofMycobacterium tuberculosis

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Salicylate reduces the antimicrobial activity of ciprofloxacin against extracellular Salmonella enterica serovar Typhimurium, but not against Salmonella in macrophages

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Crystal Structure of the Transcriptional Regulator Rv0678 of Mycobacterium tuberculosis

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Structure of the MarR family protein Rv0880 from Mycobacterium tuberculosis

21 January 2018

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Mutation of Rv2887, a marR-like gene, confers Mycobacterium tuberculosis resistance to an imidazopyridine-based agent.

21 January 2018

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Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli

21 January 2018

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21 January 2018

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Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis

21 January 2018

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Prokaryotic transcription regulators: more than just the helix-turn-helix motif

21 January 2018

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Structural and functional analysis of the transcriptional regulator Rv3066 of Mycobacterium tuberculosis

21 January 2018

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A complex regulatory network controlling intrinsic multidrug resistance in Mycobacterium smegmatis.

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A giant molecular proton pump: structure and mechanism of respiratory complex I.

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Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux

21 January 2018

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Inhibition of drug efflux in mycobacteria with phenothiazines and other putative efflux inhibitors

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Bacterial resistance to uncouplers

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The antipsychotic thioridazine shows promising therapeutic activity in a mouse model of multidrug-resistant tuberculosis

21 January 2018

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Amisulpride versus flupentixol in schizophrenia with predominantly positive symptomatology -- a double-blind controlled study comparing a selective D2-like antagonist to a mixed D1-/D2-like antagonist. The Amisulpride Study Group

21 January 2018

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Verapamil, a Ca2+ channel inhibitor acts as a local anesthetic and induces the sigma E dependent extra-cytoplasmic stress response in E. coli.

21 January 2018

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The biochemistry of P-glycoprotein-mediated multidrug resistance

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Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex

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Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis

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Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c

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Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux

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Acceleration of tuberculosis treatment by adjunctive therapy with verapamil as an efflux inhibitor

21 January 2018

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Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs

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Antitubercular pharmacodynamics of phenothiazines

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The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

21 January 2018

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Steady-state kinetics and inhibitory action of antitubercular phenothiazines on mycobacterium tuberculosis type-II NADH-menaquinone oxidoreductase (NDH-2).

21 January 2018

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Differential effects of typical and atypical neuroleptics on mitochondrial function in vitro

21 January 2018

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Characterization of the type 2 NADH:menaquinone oxidoreductases from Staphylococcus aureus and the bactericidal action of phenothiazines

21 January 2018

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Bacterial efflux pump inhibitors from natural sources.

21 January 2018

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Antimycobacterials from natural sources: ancient times, antibiotic era and novel scaffolds.

21 January 2018

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Herbal modulation of P-glycoprotein

21 January 2018

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Piperine as an inhibitor of Rv1258c, a putative multidrug efflux pump of Mycobacterium tuberculosis

21 January 2018

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Clinical concentrations of thioridazine kill intracellular multidrug-resistant Mycobacterium tuberculosis

21 January 2018

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Exploring the potential of adjunct therapy in tuberculosis

21 January 2018

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Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance: evolutionary considerations

21 January 2018

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The TB laboratory of the future: macrophage-based selection of XDR-TB therapeutics

21 January 2018

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Can the addition of verapamil to bedaquiline-containing regimens improve tuberculosis treatment outcomes? A novel approach to optimizing TB treatment.

21 January 2018

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Activity of phenothiazines against antibiotic-resistant Mycobacterium tuberculosis: a review supporting further studies that may elucidate the potential use of thioridazine as anti-tuberculosis therapy.

21 January 2018

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Verapamil increases the bactericidal activity of bedaquiline against Mycobacterium tuberculosis in a mouse model

21 January 2018

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The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents

21 January 2018

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SILA-421 activity in vitro against rifampicin-susceptible and rifampicin-resistant Mycobacterium tuberculosis, and in vivo in a murine tuberculosis model

21 January 2018

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Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy

21 January 2018

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Mycobacterium tuberculosis with disruption in genes encoding the phosphate binding proteins PstS1 and PstS2 is deficient in phosphate uptake and demonstrates reduced in vivo virulence

21 January 2018

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Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids

21 January 2018

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Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis

21 January 2018

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Rapid and spontaneous loss of phthiocerol dimycocerosate (PDIM) from Mycobacterium tuberculosis grown in vitro: implications for virulence studies

21 January 2018

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Evidence that protein antigen b of Mycobacterium tuberculosis is involved in phosphate metabolism

21 January 2018

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The Escherichia coli ATP-binding cassette (ABC) proteins.

21 January 2018

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B-subunit of phosphate-specific transporter from Mycobacterium tuberculosis is a thermostable ATPase

21 January 2018

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Role of an ABC importer in mycobacterial drug resistance

21 January 2018

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Different susceptibility of two animal species infected with isogenic mutants of Mycobacterium bovis identifies phoT as having roles in tuberculosis virulence and phosphate transport

21 January 2018

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The knockout of the lprG-Rv1410 operon produces strong attenuation of Mycobacterium tuberculosis

21 January 2018

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Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein

21 January 2018

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Characterization of a Mycobacterium avium subsp. avium operon associated with virulence and drug detoxification.

21 January 2018

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Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages

21 January 2018

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Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen

21 January 2018

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Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness

21 January 2018

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Fitness study of the RDRio lineage and Latin American-Mediterranean family of Mycobacterium tuberculosis in the city of Rio Grande, Brazil

21 January 2018

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Fitness of Mycobacterium tuberculosis strains of the W-Beijing and Non-W-Beijing genotype

21 January 2018

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Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs

21 January 2018

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Global transcriptional profiling of longitudinal clinical isolates of Mycobacterium tuberculosis exhibiting rapid accumulation of drug resistance

21 January 2018

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Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient

21 January 2018

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Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser315

21 January 2018

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Biological variability and the emergence of multidrug-resistant tuberculosis

21 January 2018

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Tuberculosis treatment and management--an update on treatment regimens, trials, new drugs, and adjunct therapies

21 January 2018

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Analysis of the proteome of Mycobacterium tuberculosis in silico

21 January 2018

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Isoniazid’s Bactericidal Activity Ceases because of the Emergence of Resistance, Not Depletion ofMycobacterium tuberculosisin the Log Phase of Growth

21 January 2018

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The role of ABC efflux pump, Rv1456c-Rv1457c-Rv1458c, from Mycobacterium tuberculosis clinical isolates in China

21 January 2018

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Mechanisms of fluoroquinolone monoresistance in Mycobacterium tuberculosis

31 March 2020

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Multidrug and toxic compound extrusion (MATE)-type proteins as anchor transporters for the excretion of metabolic waste products and xenobiotics

31 March 2020

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Isoniazid accumulation in Mycobacterium smegmatis is modulated by proton motive force-driven and ATP-dependent extrusion systems

31 March 2020

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Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina with a combination of linezolid, moxifloxacin and thioridazine

31 March 2020

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The gene encoding P27 lipoprotein and a putative antibiotic-resistance gene form an operon in Mycobacterium tuberculosis and Mycobacterium bovis

31 March 2020

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