Structural Plasticity and Distinct Drug-Binding Modes of LfrR, a Mycobacterial Efflux Pump Regulator (Q27657753)

1

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Francis Schaeffer

3

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Silvia Buroni

Silvia Buroni

2

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Giovanna Riccardi

Giovanna Riccardi

4

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Pedro M. Alzari

Pedro M Alzari

6

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Edda De Rossi

5

QacR−Cation Recognition Is Mediated by a Redundancy of Residues Capable of Charge Neutralization †

Edda De Rossi

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language of work or name

English

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publication date

December 2009

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published in

Journal of Bacteriology

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volume

191

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issue

24

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page(s)

7531-7

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cites work

1 reference

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A short history of SHELX

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Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions

20 March 2017

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Crystal Structure of the Vibrio cholerae Quorum-Sensing Regulatory Protein HapR

20 March 2017

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20 March 2017

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Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR

20 March 2017

1 reference

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Structural mechanisms of QacR induction and multidrug recognition

20 March 2017

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20 March 2017

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Version 1.2 of the Crystallography and NMR system

20 March 2017

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Automated structure solution with autoSHARP

20 March 2017

1 reference

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Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

20 March 2017

1 reference

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20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

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PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations

20 March 2017

1 reference

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The TetR family of transcriptional repressors.

20 March 2017

1 reference

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Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis

20 March 2017

1 reference

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The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis

20 March 2017

1 reference

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Efflux pumps as antimicrobial resistance mechanisms

20 March 2017

1 reference

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Molecular mechanisms of antibacterial multidrug resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

LfrR is a repressor that regulates expression of the efflux pump LfrA in Mycobacterium smegmatis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Antimicrobial resistance: factors and outcomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Role of mycobacterial efflux transporters in drug resistance: an unresolved question

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Improved solubility of TEV protease by directed evolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Mycobacterial efflux pumps and chemotherapeutic implications.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Mycobacterial porins--new channel proteins in unique outer membranes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Contribution of the multidrug efflux pump LfrA to innate mycobacterial drug resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump

29 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

29 September 2017

https://pubmed.ncbi.nlm.nih.gov/19820093

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Isothermal titration calorimetry: general formalism using binding polynomials.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Molecular flexibility in protein-DNA interactions

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Characterization of tetracycline resistance mediated by the efflux pump Tap from Mycobacterium fortuitum

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614

Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786614