O-linked mucin-type glycosylation in breast cancer (Q57107715)

2

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Rosalind Graham

3

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Joyce Taylor-Papadimitriou

4

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Virginia Tajadura-Ortega

5

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language of work or name

English

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publication date

20 August 2018

6 references

3 April 2019

19 June 2019

17 June 2019

7 August 2019

15 December 2019

20 July 2020

10

1 reference

Biochemical Society Transactions

inferred from page(s)

published in

6 references

3 April 2019

19 June 2019

17 June 2019

7 August 2019

15 December 2019

20 July 2020

46

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issue

4

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page(s)

779-788

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copyright license

Creative Commons Attribution

6 references

3 April 2019

19 June 2019

17 June 2019

7 August 2019

15 December 2019

20 July 2020

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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Targeting sialic acid-Siglec interactions to reverse immune suppression in cancer.

2 November 2018

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De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium.

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Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis.

2 November 2018

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2 November 2018

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Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells.

2 November 2018

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Unlocking Cancer Glycomes from Histopathological Formalin-fixed and Paraffin-embedded (FFPE) Tissue Microdissections.

2 November 2018

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The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9.

2 November 2018

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Precision glycocalyx editing as a strategy for cancer immunotherapy.

2 November 2018

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Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

2 November 2018

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Glycosyltransferase Gene Expression Profiles Classify Cancer Types and Propose Prognostic Subtypes

2 November 2018

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Two E-selectin ligands, BST-2 and LGALS3BP, predict metastasis and poor survival of ER-negative breast cancer.

2 November 2018

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Targeting Selectins and Their Ligands in Cancer

2 November 2018

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Symbol Nomenclature for Graphical Representations of Glycans

2 November 2018

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Glycosylation in cancer: mechanisms and clinical implications

2 November 2018

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Down-regulation of α-L-fucosidase 1 expression confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface

2 November 2018

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Loss of Core 1-derived O-Glycans Decreases Breast Cancer Development in Mice

2 November 2018

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The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL.

2 November 2018

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Simple sugars to complex disease--mucin-type O-glycans in cancer

2 November 2018

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High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

2 November 2018

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Tumor-stroma crosstalk: targeting stroma in breast cancer.

2 November 2018

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Siglec-mediated regulation of immune cell function in disease.

2 November 2018

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Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

2 November 2018

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Immature truncated O-glycophenotype of cancer directly induces oncogenic features

2 November 2018

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The cancer glycocalyx mechanically primes integrin-mediated growth and survival

2 November 2018

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Sialyl-tn in cancer: (how) did we miss the target?

2 November 2018

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A soluble form of Siglec-9 provides an antitumor benefit against mammary tumor cells expressing MUC1 in transgenic mice.

2 November 2018

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Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance

2 November 2018

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An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor

2 November 2018

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Quantitative assessment of Tn antigen in breast tissue micro-arrays using CdSe aqueous quantum dots

2 November 2018

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Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

2 November 2018

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Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth

2 November 2018

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Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness.

2 November 2018

1 reference

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Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers

2 November 2018

1 reference

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Site-specific protein O-glycosylation modulates proprotein processing - deciphering specific functions of the large polypeptide GalNAc-transferase gene family

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Since there are PAMPs and DAMPs, there must be SAMPs? Glycan “self-associated molecular patterns” dampen innate immunity, but pathogens can mimic them

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Golgi pH, its regulation and roles in human disease

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Tumour-associated carbohydrate antigens in breast cancer

2 November 2018

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Over-expression of ST3Gal-I promotes mammary tumorigenesis

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymes

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

N-Acetylgalactosaminyltransferase-14 as a potential biomarker for breast cancer by immunohistochemistry

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Critical roles of mucin 1 glycosylation by transactivated polypeptide N-acetylgalactosaminyltransferase 6 in mammary carcinogenesis

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Elevated Golgi pH impairs terminal N-glycosylation by inducing mislocalization of Golgi glycosyltransferases

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Mammalian glycosylation in immunity

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Absence of COSMC gene mutations in breast and colorectal carcinomas.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Immunolocalisation of members of the polypeptide N-acetylgalactosaminyl transferase (ppGalNAc-T) family is consistent with biologically relevant altered cell surface glycosylation in breast cancer

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (ppGalNAc-T6) mRNA as a potential new marker for detection of bone marrow-disseminated breast cancer cells.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Elevated Golgi pH in breast and colorectal cancer cells correlates with the expression of oncofetal carbohydrate T-antigen

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

ST6GalNAc I expression in MDA-MB-231 breast cancer cells greatly modifies their O-glycosylation pattern and enhances their tumourigenicity.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Sialylated core 1 based O-linked glycans enhance the growth rate of mammary carcinoma cells in MUC1 transgenic mice

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

O-linked glycosylation in the mammary gland: changes that occur during malignancy.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Concentrations of galectin-3 in the sera of normal controls and cancer patients

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

A transfected sialyltransferase that is elevated in breast cancer and localizes to the medial/trans-Golgi apparatus inhibits the development of core-2-based O-glycans

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Comparison of O-linked carbohydrate chains in MUC-1 mucin from normal breast epithelial cell lines and breast carcinoma cell lines. Demonstration of simpler and fewer glycan chains in tumor cells.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoietic tissues.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Expression of sialyl-Tn predicts the effect of adjuvant chemotherapy in node-positive breast cancer

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

Changes in a surface-labelled galactoprotein and in glycolipid concentrations in cells transformed by a temperature-sensitive polyoma virus mutant

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6103458

A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas

2 November 2018

1 reference

12 December 2020

T and Tn, general carcinoma autoantigens

1 reference

12 December 2020

High density O-glycosylation on tandem repeat peptide from secretory MUC1 of T47D breast cancer cells

1 reference

12 December 2020

An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas

1 reference

12 December 2020