Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus (Q56899717)

Michael R Ehrenstein

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David A. Isenberg

David A Isenberg

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Fabian Flores-Borja

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Fabian Flores-Borja

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Elizabeth C Jury

1

Elizabeth C Jury

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author name string

Hardeep S Kalsi

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Mark Lazarus

European Journal of Immunology

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language of work or name

English

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publication date

February 2010

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published in

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volume

40

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issue

2

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page(s)

569-78

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cites work

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Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus

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Agrin signalling contributes to cell activation and is overexpressed in T lymphocytes from lupus patients

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Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus

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Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

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Atorvastatin restores Lck expression and lipid raft-associated signaling in T cells from patients with systemic lupus erythematosus.

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Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus

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CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.

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Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function

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Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.

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Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

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Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

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CTLA-4 control over Foxp3+ regulatory T cell function

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Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain

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Abnormal T cell signal transduction in systemic lupus erythematosus

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Reversal of the TCR stop signal by CTLA-4

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CTLA-4 gene polymorphism in promoter and exon-1 regions in Chinese patients with systemic lupus erythematosus

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CTLA-4 gene polymorphisms in systemic lupus erythematosus: a highly significant association with a determinant in the promoter region

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Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus

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CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis

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Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study

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Clinical manifestations and analyses of the cytotoxic T-lymphocyte associated-4 gene in two Japanese families with systemic lupus erythematosus.

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Expression of CTLA-4 molecule in peripheral blood T lymphocytes from patients with systemic lupus erythematosus

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Differential expression of CTLA-4 among T cell subsets

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Decreased T cell response to anti-CD2 in systemic lupus erythematosus and reversal by anti-CD28: evidence for impaired T cell-accessory cell interaction

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Preferential elimination of CD28+ T cells in systemic lupus erythematosus (SLE) and the relation with activation-induced apoptosis

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Regulatory T cells in systemic lupus erythematosus: past, present and future

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Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor

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CTLA4 mediates antigen-specific apoptosis of human T cells

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Increased T-lymphocyte apoptosis/necrosis and IL-10 producing cells in patients and their spouses in Icelandic systemic lupus erythematosus multicase families

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Enhanced propensity of T lymphocytes in patients with systemic lupus erythematosus to apoptosis in the presence of tumour necrosis factor alpha

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Increased T-lymphocyte apoptosis in lupus correlates with disease activity and may be responsible for reduced T-cell frequency: a cross-sectional and longitudinal study

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Decreased effector memory CD45RA+ CD62L- CD8+ T cells and increased central memory CD45RA- CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients

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Abnormal differentiation of memory T cells in systemic lupus erythematosus

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A polymorphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4) gene (exon 1 +49) alters T-cell activation

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T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor.

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Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation

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T- and B-cell abnormalities in systemic lupus erythematosus

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A native soluble form of CTLA-4

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Increased expression of soluble cytotoxic T-lymphocyte-associated antigen-4 molecule in patients with systemic lupus erythematosus

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Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus

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Global Natural Regulatory T Cell Depletion in Active Systemic Lupus Erythematosus

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Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

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Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

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Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

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FOXP3 Identifies Regulatory CD25brightCD4+ T Cells in Rheumatic Joints

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Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia

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T effectors outfox T regulators in autoimmunity

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Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity

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7 January 2021

CTLA-4 can function as a negative regulator of T cell activation

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7 January 2021