Abnormal T cell signal transduction in systemic lupus erythematosus (Q34736534)

4 August 2017

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title

Abnormal T cell signal transduction in systemic lupus erythematosus (English)

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systemic lupus erythematosus

4 August 2017

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author name string

Gary M Kammer

1

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4 August 2017

Andras Perl

2

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4 August 2017

Bruce C Richardson

3

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4 August 2017

George C Tsokos

4

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4 August 2017

1 May 2002

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4 August 2017

Arthritis & Rheumatology

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4 August 2017

46

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4 August 2017

1139-1154

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4 August 2017

5

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Systemic lupus erythematosus in the elderly.

4 August 2017

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Impaired recovery and cytolytic function of CD56+ T and non-T cells in systemic lupus erythematosus following in vitro polyclonal T cell stimulation. Studies in unselected patients and monozygotic disease-discordant twins

21 January 2018

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The immunoregulatory effects of NK cells: the role of TGF-beta and implications for autoimmunity

21 January 2018

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The T cell enigma in lupus

21 January 2018

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Molecular aberrations in human systemic lupus erythematosus

21 January 2018

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Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus

21 January 2018

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Leukocyte protein tyrosine kinases: potential targets for drug discovery

21 January 2018

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Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain

21 January 2018

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T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor zeta chain messenger RNA.

21 January 2018

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Generation and biochemical analysis of human effector CD4 T cells: alterations in tyrosine phosphorylation and loss of CD3zeta expression

21 January 2018

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Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus

21 January 2018

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Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production

21 January 2018

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Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes

21 January 2018

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Adenylyl cyclases and the interaction between calcium and cAMP signalling

21 January 2018

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Regulation of Ca2+ release by cAMP-dependent protein kinase. A mechanism for agonist-specific calcium signaling?

21 January 2018

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CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line

21 January 2018

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cAMP inhibits the OKT3-induced increase in cytoplasmic free calcium in the Jurkat T cell line: the degree of inhibition correlates inversely with the amount of CD3 binding ligand used

21 January 2018

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Increased intracellular cyclic AMP inhibits inositol phospholipid hydrolysis induced by perturbation of the T cell receptor/CD3 complex but not by G-protein stimulation. Association with protein kinase A-mediated phosphorylation of phospholipase C-g

21 January 2018

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Inhibition of inositol 1,4,5-trisphosphate-induced Ca2+ release by cAMP-dependent protein kinase in a living cell

21 January 2018

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Abnormal adenosine-induced immunosuppression and cAMP metabolism in T lymphocytes of patients with systemic lupus erythematosus

21 January 2018

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Defective cAMP-dependent phosphorylation of intact T lymphocytes in active systemic lupus erythematosus

21 January 2018

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Impaired mobility of human T lymphocyte surface molecules during inactive systemic lupus erythematosus. Relationship to a defective cAMP pathway

21 January 2018

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Impaired T cell capping and receptor regeneration in active systemic lupus erythematosus. Evidence for a disorder intrinsic to the T lymphocyte

21 January 2018

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Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes

21 January 2018

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Association of deficient type II protein kinase A activity with aberrant nuclear translocation of the RII beta subunit in systemic lupus erythematosus T lymphocytes

21 January 2018

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Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production

21 January 2018

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Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus

21 January 2018

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A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families

21 January 2018

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Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees

21 January 2018

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Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families

21 January 2018

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Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7

21 January 2018

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Apoptosis and programmed cell death in immunity

21 January 2018

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21 January 2018

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The apoptosis-1/Fas protein in human systemic lupus erythematosus

21 January 2018

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Defective CD3-mediated cell death in activated T cells from patients with systemic lupus erythematosus: role of decreased intracellular TNF-alpha.

21 January 2018

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The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

21 January 2018

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BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

21 January 2018

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p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.

21 January 2018

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Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C.

21 January 2018

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Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses

21 January 2018

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Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand

21 January 2018

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Prospective measure of serum 3-nitrotyrosine levels in systemic lupus erythematosus: correlation with disease activity

21 January 2018

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BCL-2 family members and the mitochondria in apoptosis

21 January 2018

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Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis

21 January 2018

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Role of free radicals and catalytic metal ions in human disease: an overview

21 January 2018

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Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms

21 January 2018

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Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens

21 January 2018

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Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

21 January 2018

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Methylation-induced repression--belts, braces, and chromatin

21 January 2018

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Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice

21 January 2018

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Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice

21 January 2018

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CD4(+) T cells from lupus-prone mice are hyperresponsive to T cell receptor engagement with low and high affinity peptide antigens: a model to explain spontaneous T cell activation in lupus

21 January 2018

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Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway

21 January 2018

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Analysis of proteins that interact with the IL-2 regulatory region in patients with rheumatic diseases

21 January 2018

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The Ras signal transduction pathway

21 January 2018

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

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Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus

21 January 2018

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Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2

21 January 2018

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Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene

21 January 2018

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Coupling gene expression to cAMP signalling: role of CREB and CREM.

21 January 2018

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Transcriptional regulation by cyclic AMP.

21 January 2018

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PKR; a sentinel kinase for cellular stress

21 January 2018

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PKR, apoptosis and cancer

21 January 2018

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Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation

21 January 2018

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Impaired translational response and increased protein kinase PKR expression in T cells from lupus patients

21 January 2018

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Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells

21 January 2018

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An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

21 January 2018

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Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus

21 January 2018

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Inflammation in autoimmunity: receptors for IgG revisited

21 January 2018

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Protein kinase Ctheta: a new essential superstar on the T-cell stage

21 January 2018

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Association of IL-6 gene alleles with systemic lupus erythematosus (SLE) and with elevated IL-6 expression

21 January 2018

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Role of covalent modifications of histones in regulating gene expression

21 January 2018

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Histone acetylases and deacetylases in cell proliferation

21 January 2018

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Histone deacetylases: silencers for hire.

21 January 2018

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Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells

21 January 2018

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Glutathione Levels and Sensitivity to Apoptosis Are Regulated by Changes in Transaldolase Expression

21 January 2018

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From TCR Engagement to T Cell Activation

21 January 2018

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Serum interleukin 10 titers in systemic lupus erythematosus reflect disease activity

21 January 2018

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Immune cell signaling defects in lupus: activation, anergy and death

21 January 2018

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Diminished levels of T cell receptor zeta chains in peripheral blood T lymphocytes from patients with systemic lupus erythematosus

21 January 2018

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Polymorphisms/mutations of TCR-zeta-chain promoter and 3' untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3' untranslated region in patients with systemic lupus erythematosus

21 January 2018

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Increased expression of functional Fas-ligand in activated T cells from patients with systemic lupus erythematosus

21 January 2018

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Increased proto-oncogene expression in peripheral blood lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases

21 January 2018

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High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus

21 January 2018

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mRNA mutations of type I protein kinase A regulatory subunit alpha in T lymphocytes of a subject with systemic lupus erythematosus

21 January 2018

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Role of reactive oxygen intermediates in interleukin 10 release after cold liver ischemia and reperfusion in mice

21 January 2018

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High levels of bcl-2 protein in circulating T lymphocytes, but not B lymphocytes, of patients with systemic lupus erythematosus

21 January 2018

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Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

21 January 2018

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Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis

21 January 2018

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Lymphocyte function-associated antigen 1 overexpression and T cell autoreactivity

21 January 2018

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Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients

21 January 2018

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Role of the ras-MAPK signaling pathway in the DNA methyltransferase response to DNA hypomethylation

21 January 2018

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Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus

21 January 2018

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A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus

21 January 2018

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p56lck activity and expression in peripheral blood lymphocytes from patients with systemic lupus erythematosus

21 January 2018

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Reduced protein tyrosine phosphatase (PTPase) activity of CD45 on peripheral blood lymphocytes in patients with systemic lupus erythematosus (SLE)

21 January 2018

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Abnormal pattern of tyrosine phosphorylation in unstimulated peripheral blood T lymphocytes from patients with systemic lupus erythematosus

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ART.10192

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4 August 2017

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