Jump to content

HRas proto-oncogene, GTPase (Q5635781)

From Wikidata
mammalian protein found in Homo sapiens
  • HRAS
  • Ras family small GTP binding protein H-Ras
  • p21ras
  • K-Ras 2
  • transforming protein p21
  • Ha-Ras
  • c-has/bas p21 protein
  • Ha-Ras1 proto-oncoprotein
  • GTPase HRas
  • transformation gene: oncogene HAMSV
  • GTP- and GDP-binding peptide B
  • v-Ha-ras Harvey rat sarcoma viral oncogene homolog
  • H-Ras-1
  • c-ras-Ki-2 activated oncogene
  • c-H-ras
  • p19 H-RasIDX protein
  • Harvey rat sarcoma viral oncogene homolog
  • Harvey rat sarcoma viral oncoprotein
  • GTPase KRas
edit
Language Label Description Also known as
default for all languages
No label defined
    English
    HRas proto-oncogene, GTPase
    mammalian protein found in Homo sapiens
    • HRAS
    • Ras family small GTP binding protein H-Ras
    • p21ras
    • K-Ras 2
    • transforming protein p21
    • Ha-Ras
    • c-has/bas p21 protein
    • Ha-Ras1 proto-oncoprotein
    • GTPase HRas
    • transformation gene: oncogene HAMSV
    • GTP- and GDP-binding peptide B
    • v-Ha-ras Harvey rat sarcoma viral oncogene homolog
    • H-Ras-1
    • c-ras-Ki-2 activated oncogene
    • c-H-ras
    • p19 H-RasIDX protein
    • Harvey rat sarcoma viral oncogene homolog
    • Harvey rat sarcoma viral oncoprotein
    • GTPase KRas

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    45 references
    retrieved
    1 January 2018
    stated in
    Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The complex of Arl2-GTP and PDE delta: from structure to function
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Prenylated Rab acceptor protein is a receptor for prenylated small GTPases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Identification of a novel Rac1-interacting protein involved in membrane ruffling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Protein binding and signaling properties of RIN1 suggest a unique effector function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Ras membrane orientation and nanodomain localization generate isoform diversity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A human MAP kinase interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Catalytic competence of the Ras-GEF domain of hSos1 requires intra-REM domain interactions mediated by phenylalanine 577
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Regulation of Sos Activity by Intramolecular Interactions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Allosteric gating of Son of sevenless activity by the histone domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The structural basis of the activation of Ras by Sos
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural analysis of autoinhibition in the Ras activator Son of sevenless
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A novel switch region regulates H-ras membrane orientation and signal output
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Identification of Nore1 as a potential Ras effector
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Membrane-dependent signal integration by the Ras activator Son of sevenless
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IPI
    GTP binding
    determination method or standard
    IDA
    IEA
    IMP
    6 references
    retrieved
    1 January 2018
    stated in
    Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IDA
    cell component
    plasma membrane
    determination method or standard
    IDA
    IEA
    TAS
    8 references
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation
    GOA
    curator
    Proteome Inc.
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    Ras activation in platelets after stimulation of the thrombin receptor, thromboxane A2 receptor or protein kinase C
    GOA
    curator
    Proteome Inc.
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus
    GOA
    curator
    UniProt
    UniProt protein ID
    P01112
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Spatial regulation of Raf kinase signaling by RKTG
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus
    GOA
    curator
    Community Assessment of Community Annotation with Ontologies
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112
    determination method or standard
    IDA
    biological process

    Identifiers

    PDB structure ID
     
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    edit
                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q5635781&oldid=2090736270"