Pro-apoptotic activity of oncogenic H-Ras for histone deacetylase inhibitor to induce apoptosis of human cancer HT29 cells (Q54964870)

12 December 2020

The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?

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12 December 2020

A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation

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12 December 2020

Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells

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12 December 2020

Substrate specificities of caspase family proteases

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12 December 2020

FR-901228 Fujisawa/National Cancer Institute.

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12 December 2020

A serine protease is involved in the initiation of DNA damage-induced apoptosis

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12 December 2020

The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway

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12 December 2020

Prospects: histone deacetylase inhibitors

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12 December 2020

The capacity for growth stimulation by TGF beta 1 seen only in advanced colon cancers cannot be ascribed to mutations in APC, DCC, p53 or ras.

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12 December 2020

FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells

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12 December 2020

Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

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12 December 2020

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

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12 December 2020

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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12 December 2020

Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide

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12 December 2020

Detection of a novel quiescence-dependent protein kinase

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12 December 2020

Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells.

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12 December 2020

Oncogenic Ras sensitizes normal human cells to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis

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12 December 2020

Raf kinase as a target for anticancer therapeutics

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12 December 2020

Ras signaling in tumor necrosis factor-induced apoptosis.

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12 December 2020

Distinct roles of the ERK pathway in modulating apoptosis of Ras-transformed and non-transformed cells induced by anticancer agent FR901228.

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12 December 2020

Increasing complexity of Ras signaling.

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12 December 2020

Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

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12 December 2020

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity

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12 December 2020

Raf and the road to cell survival: a tale of bad spells, ring bearers and detours

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12 December 2020

Heterochromatin and epigenetic control of gene expression

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12 December 2020

Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP.

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12 December 2020

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

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12 December 2020

Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1)

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12 December 2020

Bcl-2 targets the protein kinase Raf-1 to mitochondria

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12 December 2020

Blocking oncogenic Ras signaling for cancer therapy

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12 December 2020

Acetyltransferase machinery conserved in p300/CBP-family proteins

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12 December 2020

Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil

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12 December 2020

A review of depsipeptide and other histone deacetylase inhibitors in clinical trials

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12 December 2020

New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

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12 December 2020

P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

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12 December 2020

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

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12 December 2020

Mechanisms of caspase activation

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12 December 2020

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice

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12 December 2020

Histone modifications as a platform for cancer therapy

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12 December 2020

Potentiated caspase-3 in Ras-transformed 10T1/2 cells

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12 December 2020

Histone deacetylase inhibitor FK228 suppresses the Ras-MAP kinase signaling pathway by upregulating Rap1 and induces apoptosis in malignant melanoma

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12 December 2020

The molecular biology of cancer

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12 December 2020

Ha-rasVal12 oncogene increases susceptibility of NIH/3T3 cells to lovastatin.

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12 December 2020

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein

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12 December 2020

Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis.

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12 December 2020

FK228 (depsipeptide): a HDAC inhibitor with pleiotropic antitumor activities

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12 December 2020

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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12 December 2020

The histone deacetylase inhibitor FR901228 induces caspase-dependent apoptosis via the mitochondrial pathway in small cell lung cancer cells

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12 December 2020

Differential modulation of signaling pathways and apoptosis of ras-transformed 10T1/2 cells by the depsipeptide FR901228.

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12 December 2020

Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin

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12 December 2020