Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response. (Q54740910)

3 June 2018

title

Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response. (English)

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3 June 2018

author

Thomas L Saunders

4

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3 June 2018

author name string

Ryan L Ragland

1

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3 June 2018

Martin F Arlt

2

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3 June 2018

Elizabeth D Hughes

3

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3 June 2018

Thomas W Glover

5

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3 June 2018

publication date

7 June 2009

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3 June 2018

number of pages

11

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inferred from page(s)

published in

Mammalian Genome

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3 June 2018

volume

20

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3 June 2018

page(s)

375-385

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issue

6

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3 June 2018

https://scigraph.springernature.com/pub.10.1007/s00335-009-9195-4

exact match

0 references

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

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An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

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Floxed allele for conditional inactivation of the voltage-gated sodium channel Scn8a (NaV1.6).

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The ATM-mediated DNA-damage response: taking shape.

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Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway.

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

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Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles.

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High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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12 December 2020

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

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Establishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell lines.

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Interplay between ATM and ATR in the regulation of common fragile site stability

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Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance

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12 December 2020

10.1007/S00335-009-9195-4

Identifiers

DOI

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3 June 2018

PubMed ID

19504344

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3 June 2018