DOC-MEK: a double-blind randomized phase II trial of docetaxel with or without selumetinib in wild-type BRAF advanced melanoma. (Q54375138)

29 May 2018

title

DOC-MEK: a double-blind randomized phase II trial of docetaxel with or without selumetinib in wild-type BRAF advanced melanoma. (English)

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main subject

phase II clinical trial

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Christian H. Ottensmeier

9

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Paul Lorigan

10

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author name string

A Gupta

1

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S Love

2

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A Schuh

3

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M Shanyinde

4

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J M Larkin

5

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R Plummer

6

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P D Nathan

7

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S Danson

8

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L Collins

11

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A Wise

12

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R Asher

13

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R Lisle

14

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M R Middleton

15

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publication date

24 February 2014

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published in

Annals of Oncology

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volume

25

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issue

5

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page(s)

968-974

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29 May 2018

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

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Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

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Improved survival with vemurafenib in melanoma with BRAF V600E mutation

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Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

21 January 2018

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The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel

21 January 2018

1 reference

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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

21 January 2018

1 reference

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Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDU054

Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study

21 January 2018

1 reference

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Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2.

21 January 2018

1 reference

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Docetaxel-induced apoptosis of human melanoma is mediated by activation of c-Jun NH2-terminal kinase and inhibited by the mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway

21 January 2018

1 reference

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The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models

21 January 2018

1 reference

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Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study

21 January 2018

1 reference

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Improved survival with MEK inhibition in BRAF-mutated melanoma

21 January 2018

1 reference

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MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study

21 January 2018

1 reference

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NRAS mutation status is an independent prognostic factor in metastatic melanoma

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/ANNONC/MDU054

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29 May 2018

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29 May 2018