Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis. (Q54362642)

From Wikidata

Jump to navigation Jump to search

scientific article

Language	Label	Description	Also known as
English	Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis.	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

acute myeloid leukemia

1 reference

based on heuristic

inferred from title

Sandra Marmiroli

16

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Jessika Bertacchini

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Patrizia Barozzi

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

11

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

13

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

15

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

M Guida

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

B Accordi

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

A M Martelli

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

E Petricoin

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

L Liotta

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

G Milani

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

M Giordan

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

F Forghieri

12

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

L Cocco

14

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

publication date

4 April 2014

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

28

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

11

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

2197-2205

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

https://scigraph.springernature.com/pub.10.1038/leu.2014.123

0 references

Gene expression profiling in MDS and AML: potential and future avenues.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Acute myeloid leukaemia in adults

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Targeting the KIT activating switch control pocket: a novel mechanism to inhibit neoplastic mast cell proliferation and mast cell activation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Targeting receptor tyrosine kinase signaling in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Functional proteomic profiling of AML predicts response and survival

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Defining the role of mTOR in cancer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

The nuts and bolts of AGC protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapse.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Development of PI3K inhibitors: lessons learned from early clinical trials

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Phase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Drug combination studies and their synergy quantification using the Chou-Talalay method

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Reverse-phase protein microarrays for theranostics and patient tailored therapy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Targeting mTOR for the treatment of AML. New agents and new directions

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Small-molecule inhibitors of the PI3K signaling network

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Global phosphoproteome analysis of human bone marrow reveals predictive phosphorylation markers for the treatment of acute myeloid leukemia with quizartinib

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

AKT is a therapeutic target in myeloproliferative neoplasms

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Transient exposure to quizartinib mediates sustained inhibition of FLT3 signaling while specifically inducing apoptosis in FLT3-activated leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.123

21 January 2018

Reverse-phase protein microarrays (RPPA) as a diagnostic and therapeutic guide in multidrug resistant leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24699302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of mTOR inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/24699302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo analysis of insulin-like growth factor type 1 receptor humanized monoclonal antibody MK-0646 and small molecule kinase inhibitor OSI-906 in colorectal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24699302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/LEU.2014.123

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q54362642&oldid=1708880530"