Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4. (Q54336370)

28 May 2018

title

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4. (English)

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28 May 2018

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Rik F P Schelbergen

1

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28 May 2018

Arjen B Blom

2

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28 May 2018

Martijn H J van den Bosch

3

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28 May 2018

Annet Slöetjes

4

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28 May 2018

Shahla Abdollahi-Roodsaz

5

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28 May 2018

B Wim Schreurs

6

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28 May 2018

John S Mort

7

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28 May 2018

Thomas Vogl

8

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Johannes Roth

9

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28 May 2018

Wim B van den Berg

10

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28 May 2018

Peter L E M van Lent

11

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28 May 2018

publication date

1 May 2012

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28 May 2018

published in

Arthritis and Rheumatism

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28 May 2018

volume

64

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28 May 2018

page(s)

1477-1487

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28 May 2018

issue

5

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28 May 2018

Osteoarthritis year 2010 in review: pathomechanisms

cites work

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The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

21 January 2018

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Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?

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Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients.

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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

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The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

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The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis

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Alarmins: chemotactic activators of immune responses

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S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules

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S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)

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Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

21 January 2018

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Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis

21 January 2018

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RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis

21 January 2018

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Proinflammatory S100 proteins in arthritis and autoimmune disease

21 January 2018

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S100A8 and S100A9 in experimental osteoarthritis.

21 January 2018

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Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry

21 January 2018

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Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cations

21 January 2018

1 reference

A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling

21 January 2018

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A novel anionic modification of N-glycans on mammalian endothelial cells is recognized by activated neutrophils and modulates acute inflammatory responses

21 January 2018

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Cartilage in normal and osteoarthritis conditions

21 January 2018

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Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products.

21 January 2018

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The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

21 January 2018

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S100A8 and S100A9 in inflammation and cancer

21 January 2018

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Developments in the scientific understanding of osteoarthritis

21 January 2018

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Synovial tissue inflammation in early and late osteoarthritis

21 January 2018

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Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis

21 January 2018

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IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation

21 January 2018

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Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis

21 January 2018

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Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products

21 January 2018

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S100A8 causes a shift toward expression of activatory Fcγ receptors on macrophages via toll-like receptor 4 and regulates Fcγ receptor expression in synovium during chronic experimental arthritis.

21 January 2018

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Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13.

21 January 2018

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Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes

21 January 2018

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S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway

21 January 2018

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S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products

21 January 2018

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Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ART.33495

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28 May 2018

PubMed ID

22127564

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28 May 2018