Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys. (Q54281359)

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3 March 2020

title

Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys (English)

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Manuel Serrano

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Ana Ortega-Molina

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Kelli Vaughan

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Ismael González-García

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Miguel López

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Sonia Martinez

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Joaquín Pastor

14

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author name string

Elena Lopez-Guadamillas

2

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Julie A Mattison

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Sarah J Mitchell

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Maribel Muñoz-Martin

5

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Gema Iglesias

6

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Vincent M Gutierrez

7

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Mark D Szarowicz

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David Cebrián

12

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publication date

26 March 2015

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3 March 2020

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volume

21

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issue

4

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page(s)

558-570

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Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive

3 March 2020

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Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

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Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

28 May 2018

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Targeting the PI3K pathway in the brain--efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier

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Pten positively regulates brown adipose function, energy expenditure, and longevity

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28 May 2018

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PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

28 May 2018

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Ablation of PI3K p110-α prevents high-fat diet-induced liver steatosis

28 May 2018

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Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance

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The emerging mechanisms of isoform-specific PI3K signalling

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25817535

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12 December 2020

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The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25817535

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CMET.2015.02.017

1 reference

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3 March 2020

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3 March 2020

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