Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma. (Q53325005)

13 May 2018

title

Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma. (English)

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13 May 2018

author

Norman L. Lehman

2

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13 May 2018

author name string

Ines Gütgemann

1

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13 May 2018

Peter K Jackson

3

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13 May 2018

Teri A Longacre

4

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13 May 2018

publication date

18 January 2008

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13 May 2018

published in

Modern Pathology

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13 May 2018

volume

21

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13 May 2018

page(s)

445-454

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13 May 2018

issue

4

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13 May 2018

https://scigraph.springernature.com/pub.10.1038/modpathol.3801022

exact match

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cites work

Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Subclassification of ovarian surface epithelial tumors based on correlation of histologic and molecular pathologic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Cyclins and cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Emi1 is required for cytostatic factor arrest in vertebrate eggs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Distinction between serous tumors of low malignant potential and serous carcinomas based on global mRNA expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Gene expression patterns in ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Cytogenetic alterations in ovarian clear cell carcinoma detected by comparative genomic hybridisation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Alterations of anaphase-promoting complex genes in human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Molecular pathogenesis of ovarian borderline tumors: new insights and old challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

Molecular genetic defects in endometriosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

High frequency of beta-catenin mutations in borderline endometrioid tumours of the ovary.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

PIK3CA mutations in advanced ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

p53 mutation is infrequent in clear cell carcinoma of the ovary

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

7 January 2021

TP53 protein accumulation and gene mutation in relation to overexpression of MDM2 protein in ovarian borderline tumours and stage I carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

7 January 2021

Ovarian tumors associated with atypical endometriosis

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

7 January 2021

Clear cell carcinoma has an expression pattern of cell cycle regulatory molecules that is unique among ovarian adenocarcinomas

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

7 January 2021

Ovarian atypical endometriosis: its close association with malignant epithelial tumours

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

7 January 2021

Molecular genetic alterations in endometrioid carcinomas of the ovary: similar frequency of beta-catenin abnormalities but lower rate of microsatellite instability and PTEN alterations than in uterine endometrioid carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.3801022

7 January 2021

10.1038/MODPATHOL.3801022

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DOI

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13 May 2018

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13 May 2018