Protein motions and dynamic effects in enzyme catalysis. (Q53225034)

12 May 2018

http://europepmc.org/abstract/MED/25854702

title

Protein motions and dynamic effects in enzyme catalysis. (English)

1 reference

12 May 2018

http://europepmc.org/abstract/MED/25854702

author

Louis Y P Luk

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854702%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Edric Joel Loveridge

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854702%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Rudolf K Allemann

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854702%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

language of work or name

English

0 references

publication date

1 December 2015

1 reference

12 May 2018

http://europepmc.org/abstract/MED/25854702

published in

Physical Chemistry Chemical Physics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854702%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

17

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854702%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854702%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

30817-30827

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854702%20AND%20SRC:MED&resulttype=core&format=json

Dynamics of proteins: elements and function

8 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Enzymatic H-transfer requires vibration-driven extreme tunneling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Barrier passage and protein dynamics in enzymatically catalyzed reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

A new conceptual framework for enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Enzyme millisecond conformational dynamics do not catalyze the chemical step

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Dynamics and dissipation in enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Solvent effects on catalysis by Escherichia coli dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

The role of large-scale motions in catalysis by dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Effects of point mutation in a flexible loop on the stability and enzymatic function of Escherichia coli dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Network of coupled promoting motions in enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Protein motions during catalysis by dihydrofolate reductases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Origin of the temperature dependence of isotope effects in enzymatic reactions: the case of dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Solvent effects on environmentally coupled hydrogen tunnelling during catalysis by dihydrofolate reductase from Thermotoga maritima

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Probing coupled motions in enzymatic hydrogen tunnelling reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Structure and dynamics of the G121V dihydrofolate reductase mutant: lessons from a transition-state inhibitor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Divergent evolution of protein conformational dynamics in dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Protein mass-modulated effects in the catalytic mechanism of dihydrofolate reductase: beyond promoting vibrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

The dynamic energy landscape of dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Catalysis by dihydrofolate reductase from the psychropiezophile Moritella profunda.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Thermal adaptation of dihydrofolate reductase from the moderate thermophile Geobacillus stearothermophilus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Purification and characterization of recombinant Thermotoga maritima dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Effect of pH on hydride transfer by Escherichia coli dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

pH-dependent conformational changes in Escherichia coli dihydrofolate reductase revealed by Raman difference spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Small temperature dependence of the kinetic isotope effect for the hydride transfer reaction catalyzed by Escherichia coli dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Effect of mutation on enzyme motion in dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Preservation of protein dynamics in dihydrofolate reductase evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Role of the occluded conformation in bacterial dihydrofolate reductases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Loop interactions during catalysis by dihydrofolate reductase from Moritella profunda

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Carbon-deuterium bonds as probes of dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Efforts toward the direct experimental characterization of enzyme microenvironments: tyrosine100 in dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Probing the Electrostatics of Active Site Microenvironments along the Catalytic Cycle for Escherichia coli Dihydrofolate Reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Are the catalytic properties of enzymes from piezophilic organisms pressure adapted?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Maintenance of native-like protein dynamics may not be required for engineering functional proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Choreographing an enzyme's dance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Protein dynamism and evolvability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Dynamic dysfunction in dihydrofolate reductase results from antifolate drug binding: modulation of dynamics within a structural state

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Effects of mutation at methionine-42 of Escherichia coli dihydrofolate reductase on stability and function: implication of hydrophobic interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Effects of a distal mutation on active site chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Pivotal role of Gly 121 in dihydrofolate reductase from Escherichia coli: the altered structure of a mutant enzyme may form the basis of its diminished catalytic performance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Extension and limits of the network of coupled motions correlated to hydride transfer in dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Hydrogen donor-acceptor fluctuations from kinetic isotope effects: a phenomenological model

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Simulations of remote mutants of dihydrofolate reductase reveal the nature of a network of residues coupled to hydride transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

A large compressibility change of protein induced by a single amino acid substitution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Automated identification of functional dynamic contact networks from X-ray crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Hydride transfer reaction catalyzed by hyperthermophilic dihydrofolate reductase is dominated by quantum mechanical tunneling and is promoted by both inter- and intramonomeric correlated motions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Comparison of coupled motions in Escherichia coli and Bacillus subtilis dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Nuclear magnetic resonance study of the role of M42 in the solution dynamics of Escherichia coli dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Enzymatic transition states and dynamic motion in barrier crossing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Protein dynamics and catalysis: the problems of transition state theory and the subtlety of dynamic control

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Fast protein motions are coupled to enzyme H-transfer reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Good vibrations in enzyme-catalysed reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

H-tunneling in the multiple H-transfers of the catalytic cycle of morphinone reductase and in the reductive half-reaction of the homologous pentaerythritol tetranitrate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Connecting protein conformational dynamics with catalytic function as illustrated in dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Functionally important conformations of the Met20 loop in dihydrofolate reductase are populated by rapid thermal fluctuations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Extremely Elevated Room-Temperature Kinetic Isotope Effects Quantify the Critical Role of Barrier Width in Enzymatic C–H Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

A link between protein structure and enzyme catalyzed hydrogen tunneling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Examining the case for the effect of barrier compression on tunneling, vibrationally enhanced catalysis, catalytic entropy and related issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Solvent dielectric effects on protein dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Slaving: solvent fluctuations dominate protein dynamics and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Dynamics of enzymatic reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Electrostatic basis for enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Mass-dependent bond vibrational dynamics influence catalysis by HIV-1 protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Heavy-enzyme kinetic isotope effects on proton transfer in alanine racemase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Protein isotope effects in dihydrofolate reductase from Geobacillus stearothermophilus show entropic-enthalpic compensatory effects on the rate constant

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

The temperature dependence of the kinetic isotope effects of dihydrofolate reductase from Thermotoga maritima is influenced by intersubunit interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Isotope effects as probes for enzyme catalyzed hydrogen-transfer reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Current Status of Transition-State Theory

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Protein dynamics and enzyme catalysis: the ghost in the machine?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Taking Ockham's razor to enzyme dynamics and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Barrier Crossing in Dihydrofolate Reductasedoes not involve a rate-promoting vibration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

The universality of enzymatic rate-temperature dependency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Effect of dimerization on the stability and catalytic activity of dihydrofolate reductase from the hyperthermophile Thermotoga maritima.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Comparative hydrogen-deuterium exchange for a mesophilic vs thermophilic dihydrofolate reductase at 25 °C: identification of a single active site region with enhanced flexibility in the mesophilic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Role of water in the catalytic cycle of E. coli dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Conformational change of the methionine 20 loop of Escherichia coli dihydrofolate reductase modulates pKa of the bound dihydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Temporally overlapped but uncoupled motions in dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Transition states of native and drug-resistant HIV-1 protease are the same

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

Are Environmentally Coupled Enzymatic Hydrogen Tunneling Reactions Influenced by Changes in Solution Viscosity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A

α-Secondary Isotope Effects as Probes of “Tunneling-Ready” Configurations in Enzymatic H-Tunneling: Insight from Environmentally Coupled Tunneling Models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CP00794A