Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation. (Q52665459)

http://europepmc.org/abstract/MED/26571108

5 May 2018

title

Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation. (English)

1 reference

http://europepmc.org/abstract/MED/26571108

5 May 2018

author

Andrew F. Hill

9

1 reference

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7 June 2020

Till Böcking

11

1 reference

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7 June 2020

Cheryl Shoubridge

5

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7 June 2020

Michael Griffin

8

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7 June 2020

Danny M. Hatters

12

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7 June 2020

author name string

Saskia Polling

1

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7 June 2020

Angelique R Ormsby

2

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7 June 2020

Rebecca J Wood

3

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7 June 2020

Kristie Lee

4

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7 June 2020

James N Hughes

6

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7 June 2020

Paul Q Thomas

7

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7 June 2020

Quill Bowden

10

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7 June 2020

publication date

16 November 2015

1 reference

http://europepmc.org/abstract/MED/26571108

5 May 2018

published in

Nature Structural & Molecular Biology

1 reference

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7 June 2020

volume

22

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7 June 2020

page(s)

1008-1015

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7 June 2020

issue

12

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https://scigraph.springernature.com/pub.10.1038/nsmb.3127

7 June 2020

exact match

0 references

cites work

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

1 reference

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

21 January 2018

1 reference

Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member.

21 January 2018

1 reference

Non-ATG-initiated translation directed by microsatellite expansions

21 January 2018

1 reference

Trinucleotide Repeat Disorders

21 January 2018

1 reference

The other trinucleotide repeat: polyalanine expansion disorders

21 January 2018

1 reference

Genetic investigation of FOXE1 polyalanine tract in thyroid diseases: new insight on the role of FOXE1 in thyroid carcinoma

21 January 2018

1 reference

An investigation into FOXE1 polyalanine tract length in premature ovarian failure.

21 January 2018

1 reference

Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence

21 January 2018

1 reference

Putting huntingtin "aggregation" in view with windows into the cellular milieu.

21 January 2018

1 reference

The role of amyloidogenic protein oligomerization in neurodegenerative disease

21 January 2018

1 reference

Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptides

21 January 2018

1 reference

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

21 January 2018

1 reference

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

21 January 2018

1 reference

Flanking sequences profoundly alter polyglutamine toxicity in yeast

21 January 2018

1 reference

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

1 reference

Molecular mechanisms underlying polyalanine diseases

21 January 2018

1 reference

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell

21 January 2018

1 reference

Conformation sensors that distinguish monomeric proteins from oligomers in live cells

21 January 2018

1 reference

Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool.

21 January 2018

1 reference

Poly-(L-alanine) expansions form core beta-sheets that nucleate amyloid assembly.

21 January 2018

1 reference

Polyalanine-based peptides as models for self-associated beta-pleated-sheet complexes

21 January 2018

1 reference

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

21 January 2018

1 reference

Tracking protein aggregation and mislocalization in cells with flow cytometry

21 January 2018

1 reference

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

21 January 2018

1 reference

Transcription factor SOX3 is involved in X-linked mental retardation with growth hormone deficiency

21 January 2018

1 reference

Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism

21 January 2018

1 reference

ARX spectrum disorders: making inroads into the molecular pathology

21 January 2018

1 reference

Unraveling the pathogenesis of ARX polyalanine tract variants using a clinical and molecular interfacing approach

21 January 2018

1 reference

Polyalanine expansion mutations in the X-linked hypopituitarism gene SOX3 result in aggresome formation and impaired transactivation.

21 January 2018

1 reference

Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation

21 January 2018

1 reference

Protein misfolding, functional amyloid, and human disease

21 January 2018

1 reference

A molecular pathogenesis for transcription factor associated poly-alanine tract expansions

21 January 2018

1 reference

Distinct pathogenetic mechanisms for PHOX2B associated polyalanine expansions and frameshift mutations in congenital central hypoventilation syndrome

21 January 2018

1 reference

A recurrent polyalanine expansion in the transcription factor FOXL2 induces extensive nuclear and cytoplasmic protein aggregation

21 January 2018

1 reference

A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration

21 January 2018

1 reference

Polyalanine-independent conformational conversion of nuclear poly(A)-binding protein 1 (PABPN1).

21 January 2018

1 reference

Trinucleotide expansions leading to an extended poly-L-alanine segment in the poly (A) binding protein PABPN1 cause fibril formation

21 January 2018

1 reference

The unresolved puzzle why alanine extensions cause disease

21 January 2018

1 reference

Oligomerization of polyalanine expanded PABPN1 facilitates nuclear protein aggregation that is associated with cell death

21 January 2018

1 reference

The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.

21 January 2018

1 reference

A helix propensity scale based on experimental studies of peptides and proteins

21 January 2018

1 reference

Uncoupling hydrophobicity and helicity in transmembrane segments. Alpha-helical propensities of the amino acids in non-polar environments.

21 January 2018

1 reference

Mechanistic insight into the pathology of polyalanine expansion disorders revealed by a mouse model for X linked hypopituitarism

21 January 2018

1 reference

Molecular pathology of expanded polyalanine tract mutations in the Aristaless-related homeobox gene

21 January 2018

1 reference

Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response.

21 January 2018

1 reference

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

21 January 2018

1 reference

A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70.

21 January 2018

1 reference

Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice.

21 January 2018

1 reference

Congenital hydrocephalus and abnormal subcommissural organ development in Sox3 transgenic mice

21 January 2018

1 reference

Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plate.

21 January 2018

1 reference

Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans

21 January 2018

1 reference

Polyalanine tract disorders and neurocognitive phenotypes

21 January 2018

2 references

https://pubmed.ncbi.nlm.nih.gov/26571108

21 January 2018

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Rate of PolyQ-Mediated Aggregation Is Dramatically Affected by the Number and Location of Surrounding Domains

1 reference

Length-dependent aggregation of uninterrupted polyalanine peptides

21 January 2018

1 reference

Determination of the sedimentation coefficient distribution by least-squares boundary modeling

31 March 2020

1 reference

Molecular characterization of HOXA13 polyalanine expansion proteins in hand-foot-genital syndrome

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.3127

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference