A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70. (Q37415669)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196953%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70 (English)

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29 February 2020

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5

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29 February 2020

author name string

Angelique R Ormsby

1

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29 February 2020

Yasmin M Ramdzan

2

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29 February 2020

Yee-Foong Mok

3

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29 February 2020

Kristijan D Jovanoski

4

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29 February 2020

language of work or name

English

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publication date

6 November 2013

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196953%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

29 February 2020

published in

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29 February 2020

volume

288

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29 February 2020

issue

52

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29 February 2020

page(s)

37192-37203

1 reference

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PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone

29 February 2020

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Disease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact Structure

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

6 September 2017

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6 September 2017

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6 September 2017

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Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle

6 September 2017

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Widespread protein aggregation as an inherent part of aging in C. elegans

6 September 2017

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Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool.

6 September 2017

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Conformation sensors that distinguish monomeric proteins from oligomers in live cells

6 September 2017

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Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

6 September 2017

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Secondary Structure of Huntingtin Amino-Terminal Region

6 September 2017

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Examining polyglutamine peptide length: a connection between collapsed conformations and increased aggregation

6 September 2017

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Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease

6 September 2017

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Thermodynamics of beta-sheet formation in polyglutamine

6 September 2017

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Single homopolypeptide chains collapse into mechanically rigid conformations

6 September 2017

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Far-red fluorescent tags for protein imaging in living tissues

6 September 2017

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Misfolded proteins partition between two distinct quality control compartments

6 September 2017

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Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH.

6 September 2017

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A polymer physics perspective on driving forces and mechanisms for protein aggregation

6 September 2017

1 reference

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Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions

6 September 2017

1 reference

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Progressive disruption of cellular protein folding in models of polyglutamine diseases.

6 September 2017

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

6 September 2017

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Pathways of chaperone-mediated protein folding in the cytosol

6 September 2017

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Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling

6 September 2017

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

6 September 2017

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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

6 September 2017

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

6 September 2017

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Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

6 September 2017

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Aggresomes: a cellular response to misfolded proteins

6 September 2017

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

6 September 2017

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Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

6 September 2017

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

6 September 2017

1 reference

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A causative link between the structure of aberrant protein oligomers and their toxicity.

6 September 2017

1 reference

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Modulation of polyglutamine inclusion formation by the Hsp70 chaperone machine.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

The intrinsic stiffness of polyglutamine peptides

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

Time-lapse analysis of aggregate formation in an inducible PC12 cell model of Huntington's disease reveals time-dependent aggregate formation that transiently delays cell death.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

Reconsidering the mechanism of polyglutamine peptide aggregation

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

2 September 2018

1 reference

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Characterizing the conformational ensemble of monomeric polyglutamine.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

2 September 2018

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Membrane-targeted green fluorescent protein reliably and uniquely marks cells through apoptotic death.

2 September 2018

1 reference

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

2 September 2018

1 reference

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Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3873573

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

2 September 2018

1 reference

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Size analysis of phospholipid vesicle preparations

2 September 2018

1 reference

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

2 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M113.486944

Trinucleotide repeat length instability and age of onset in Huntington's disease

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M113.486944

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24196953

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modeling polyglutamine pathogenesis in C. elegans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24196953

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.486944

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196953%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24196953%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference