CRISPR/Cas9 Technology as an Emerging Tool for Targeting Amyotrophic Lateral Sclerosis (ALS). (Q52430933)

1 May 2018

5 references

25 April 2019

8 September 2019

19 September 2019

18 November 2020

24 January 2021

CRISPR/Cas9 Technology as an Emerging Tool for Targeting Amyotrophic Lateral Sclerosis (ALS). (English)

1 reference

1 May 2018

amyotrophic lateral sclerosis

main subject

CRISPR

0 references

4 references

25 April 2019

8 September 2019

19 September 2019

18 November 2020

regulation of gene expression

1 reference

PubMed

biomedical investigative technique

8 September 2019

1 reference

19 September 2019

1 reference

18 November 2020

1 reference

24 January 2021

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4

1 reference

1 May 2018

Ewa Kruminis-Kaszkiel

object named as

Ewa Kruminis-Kaszkiel

series ordinal

1

0 references

Wojciech Maksymowicz

series ordinal

3

object named as

Wojciech Maksymowicz

1 reference

1 May 2018

author name string

Judyta Juranek

series ordinal

2

1 reference

1 May 2018

language of work or name

English

0 references

publication date

19 March 2018

6 references

1 May 2018

International Journal of Molecular Sciences

25 April 2019

8 September 2019

19 September 2019

18 November 2020

24 January 2021

6 references

1 May 2018

25 April 2019

8 September 2019

19 September 2019

18 November 2020

24 January 2021

19

1 reference

1 May 2018

issue

3

1 reference

1 May 2018

Creative Commons Attribution

copyright license

5 references

25 April 2019

8 September 2019

19 September 2019

18 November 2020

24 January 2021

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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22 May 2018

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Intramuscular Delivery of scAAV9-hIGF1 Prolongs Survival in the hSOD1G93A ALS Mouse Model via Upregulation of D-Amino Acid Oxidase

22 May 2018

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22 May 2018

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High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k "Helper" Proteins

22 May 2018

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The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

22 May 2018

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22 May 2018

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Lentivirus pre-packed with Cas9 protein for safer gene editing

22 May 2018

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Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing

22 May 2018

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22 May 2018

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Homology Directed Knockin of Point Mutations in the Zebrafish tardbp and fus Genes in ALS Using the CRISPR/Cas9 System

22 May 2018

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Improved delivery of Cas9 protein/gRNA complexes using lipofectamine CRISPRMAX.

22 May 2018

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One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system

22 May 2018

1 reference

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Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates.

22 May 2018

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Controlled delivery of β-globin-targeting TALENs and CRISPR/Cas9 into mammalian cells for genome editing using microinjection

22 May 2018

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The Development of TALE Nucleases for Biotechnology

22 May 2018

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CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases

22 May 2018

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Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing

22 May 2018

1 reference

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Normalization of Overexpressed α-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference

22 May 2018

1 reference

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CRISPR/Cas9-mediated endogenous protein tagging for RESOLFT super-resolution microscopy of living human cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

22 May 2018

1 reference

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Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

22 May 2018

1 reference

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Synthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseases

22 May 2018

1 reference

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CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

22 May 2018

1 reference

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Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

22 May 2018

1 reference

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Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

22 May 2018

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CRISPR-Cas systems for editing, regulating and targeting genomes

22 May 2018

1 reference

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Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

22 May 2018

1 reference

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Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

22 May 2018

1 reference

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Animal models of neurodegenerative diseases

22 May 2018

1 reference

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Genome engineering using the CRISPR-Cas9 system

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Amyotrophic Lateral Sclerosis: An update for 2013 Clinical Features, Pathophysiology, Management and Therapeutic Trials

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Viral vectors: a look back and ahead on gene transfer technology

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

RNA-guided human genome engineering via Cas9

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Multiplex genome engineering using CRISPR/Cas systems

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Current advances in using neurotrophic factors to treat neurodegenerative disorders

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

RNA-guided genetic silencing systems in bacteria and archaea

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Genetic rodent models of amyotrophic lateral sclerosis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Genome editing with engineered zinc finger nucleases

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Immune responses to gene therapy vectors: influence on vector function and effector mechanisms

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

In vivo genome editing improves motor function and extends survival in a mouse model of ALS.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877767

Amyotrophic lateral sclerosis

13 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29562705

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/IJMS19030906

1 reference

1 May 2018

PMCID

5877767

1 reference

1 May 2018

PubMed ID

29562705

1 reference

1 May 2018