Synthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseases (Q26830610)

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English	Synthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseases	scientific article

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scholarly article

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12 March 2020

3 references

13 September 2020

29 October 2020

29 April 2021

Synthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseases (English)

2 references

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100403%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

29 April 2021

neurodegeneration

4 references

25 April 2019

25 June 2019

12 September 2019

19 September 2019

1 reference

12 September 2019

biomedical investigative technique

1 reference

19 September 2019

synthetic biology

1 reference

based on heuristic

inferred from title

cell transplantation

1 reference

13 September 2020

1 reference

29 October 2020

Carmen Agustín-Pavón

1

1 reference

Europe PubMed Central

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12 March 2020

2

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author name string

Carmen Agustín-Pavón

1

1 reference

Mark Isalan

2

1 reference

language of work or name

1 reference

publication date

6 August 2014

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12 March 2020

1 October 2014

3 references

13 September 2020

29 October 2020

29 April 2021

9 references

25 April 2019

25 June 2019

12 September 2019

19 September 2019

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100403%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

13 September 2020

29 October 2020

29 April 2021

36

2 references

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12 March 2020

10

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12 March 2020

979-990

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12 March 2020

copyright license

Creative Commons Attribution 3.0 Unported

7 references

Europe PubMed Central

25 April 2019

Europe PubMed Central

25 June 2019

Europe PubMed Central

12 September 2019

Europe PubMed Central

19 September 2019

Europe PubMed Central

13 September 2020

Europe PubMed Central

29 October 2020

Europe PubMed Central

29 April 2021

copyright status

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on focus list of Wikimedia project

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CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

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Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records

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Gene therapy: a promising approach to treating spinal muscular atrophy.

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Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

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Plasma phospholipids identify antecedent memory impairment in older adults.

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Pre-Clinical Assessment of Immune Responses to Adeno-Associated Virus (AAV) Vectors

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Neurogenesis in the striatum of the adult human brain

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TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys

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Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

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Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors.

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Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

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AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction

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Parkinson's disease: the quintessential neuropsychiatric disorder

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Depression and risk of developing dementia

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Huntington's disease: from molecular pathogenesis to clinical treatment

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Distributed biological computation with multicellular engineered networks

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An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.

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28 September 2017

Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors

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A regulatory toolbox of MiniPromoters to drive selective expression in the brain

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28 September 2017

An engineered mammalian band-pass network

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Optimization algorithms for functional deimmunization of therapeutic proteins

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Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system

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28 September 2017

Measuring the activity of BioBrick promoters using an in vivo reference standard

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

28 September 2017

A tunable synthetic mammalian oscillator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

28 September 2017

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

28 September 2017

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

28 September 2017

Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

28 September 2017

Psychiatric disorders in preclinical Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

28 September 2017

Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

28 September 2017

Identification and functional analysis of human transcriptional promoters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

28 September 2017

Stimulation of homologous recombination through targeted cleavage by chimeric nucleases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

28 September 2017

Genetically encoded sender-receiver system in 3D mammalian cell culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

31 May 2018

One-step generation of different immunodeficient mice with multiple gene modifications by CRISPR/Cas9 mediated genome engineering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

31 May 2018

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

31 May 2018

Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

31 May 2018

An α-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

31 May 2018

Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

31 May 2018

Induction of angiogenesis in a mouse model using engineered transcription factors

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

31 May 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

28 November 2018

A synthetic multicellular system for programmed pattern formation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

21 January 2018

Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

21 January 2018

Synergistic and tunable human gene activation by combinations of synthetic transcription factors

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

21 January 2018

Oligonucleotide-mediated survival of motor neuron protein expression in CNS improves phenotype in a mouse model of spinal muscular atrophy.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

21 January 2018

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

21 January 2018

The hybrid cytomegalovirus enhancer/chicken beta-actin promoter along with woodchuck hepatitis virus posttranscriptional regulatory element enhances the protective efficacy of DNA vaccines

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

21 January 2018

Parkinson's disease: recent advances.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

21 January 2018

Modeling brain disease in a dish: really?

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

21 January 2018

Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

21 January 2018

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

21 January 2018

Intramuscular administration of a VEGF zinc finger transcription factor activator (VEGF-ZFP-TF) improves functional outcomes in SOD1 rats

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

21 January 2018

The biotech death of Jesse Gelsinger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312882

28 November 2018

Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomised, controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/25100403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2013 Alzheimer's disease facts and figures

1 reference

https://pubmed.ncbi.nlm.nih.gov/25100403

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-mapping projects to join forces

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400094

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/BIES.201400094

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100403%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100403%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100403%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

ResearchGate publication ID

0 references

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