Role of Non-Myocyte Gap Junctions and Connexin Hemichannels in Cardiovascular Health and Disease: Novel Therapeutic Targets? (Q52354401)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29543751%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

review article

0 references

title

Role of Non-Myocyte Gap Junctions and Connexin Hemichannels in Cardiovascular Health and Disease: Novel Therapeutic Targets? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29543751%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

main subject

cardiovascular disease

3 references

17 June 2019

12 October 2019

15 December 2019

1 reference

12 October 2019

1 reference

15 December 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29543751%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Patrizia Camelliti

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29543751%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

language of work or name

English

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publication date

15 March 2018

4 references

17 June 2019

12 October 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29543751%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Molecular Sciences

20 March 2020

published in

4 references

17 June 2019

12 October 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29543751%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29543751%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29543751%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution

20 March 2020

copyright license

3 references

17 June 2019

12 October 2019

15 December 2019

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on focus list of Wikimedia project

ScienceSource

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22 May 2018

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Cardiac fibroblasts: at the heart of myocardial remodeling

22 May 2018

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22 May 2018

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22 May 2018

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Connexin43 expression levels influence intercellular coupling and cell proliferation of native murine cardiac fibroblasts

22 May 2018

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Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells

22 May 2018

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Electrotonic myofibroblast-to-myocyte coupling increases propensity to reentrant arrhythmias in two-dimensional cardiac monolayers.

22 May 2018

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22 May 2018

Acute viral myocarditis

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Remodelling of gap junctions and connexin expression in diseased myocardium.

22 May 2018

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Risk factors for atherosclerosis and the development of preatherosclerotic intimal hyperplasia

22 May 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Mechanisms of sudden cardiac death in myocardial infarction survivors: insights from the randomized trials of implantable cardioverter-defibrillators

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

The role of TGF-beta signaling in myocardial infarction and cardiac remodeling

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Connexin37 protects against atherosclerosis by regulating monocyte adhesion

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Cardiac fibroblasts: friend or foe?

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Endothelial-cardiomyocyte interactions in cardiac development and repair

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Cardiomyocytes structure, function and associated pathologies

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Structural and functional characterisation of cardiac fibroblasts

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Gap junctions and the connexin protein family

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Loss of connexin45 causes a cushion defect in early cardiogenesis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Connexin37 reduces smooth muscle cell proliferation and intimal hyperplasia in a mouse model of carotid artery ligation.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Macrophages Facilitate Electrical Conduction in the Heart.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Dynamics of Cell Generation and Turnover in the Human Heart.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Rutaecarpine prevented dysfunction of endothelial gap junction induced by Ox-LDL via activation of TRPV1.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Myoendothelial coupling is unidirectional in guinea pig spiral modiolar arteries

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitro.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Connexin32 protects against vascular inflammation by modulating inflammatory cytokine expression by endothelial cells

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Loss of connexin40 is associated with decreased endothelium-dependent relaxations and eNOS levels in the mouse aorta.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Novel connexin40 missense mutations in patients with familial atrial fibrillation

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Cardiomyocyte cell cycle control and growth estimation in vivo--an analysis based on cardiomyocyte nuclei

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

The connexin43 carboxyl-terminal peptide ACT1 modulates the biological response to silicone implants.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Connexin mimetic peptides improve cell migration rates of human epidermal keratinocytes and dermal fibroblasts in vitro.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Implication of connexins 40 and 43 in functional coupling between mouse cardiac fibroblasts in primary culture.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Electrotonic modulation of cardiac impulse conduction by myofibroblasts.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Reduced expression of endothelial connexins 43 and 37 in hypertensive rats is rectified after 7-day carvedilol treatment.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Reduced expression of endothelial connexin37 and connexin40 in hyperlipidemic mice: recovery of connexin37 after 7-day simvastatin treatment

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Electrical coupling between endothelial cells and smooth muscle cells in hamster feed arteries: role in vasomotor control.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Fibroblast–myocyte connections in the heart

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5877727

Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice

30 November 2018

1 reference

12 December 2020

Incidence of Myoendothelial Gap Junctions in the Proximal and Distal Mesenteric Arteries of the Rat Is Suggestive of a Role in Endothelium-Derived Hyperpolarizing Factor–Mediated Responses

1 reference

12 December 2020

Role of gap junctions in cardiac conduction and development: insights from the connexin knockout mice

1 reference

12 December 2020

Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia

1 reference

12 December 2020

Altered connexin expression in human congestive heart failure

1 reference

12 December 2020

Gap junction remodeling and altered connexin43 expression in the failing human heart

1 reference

12 December 2020

Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin

1 reference

12 December 2020

Model-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs

1 reference

12 December 2020

Mapping of epicardial activation in a rabbit model of chronic myocardial infarction:

1 reference

12 December 2020

Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouse

1 reference

12 December 2020

Myofibroblasts induce ectopic activity in cardiac tissue

1 reference

12 December 2020

Complete atrioventricular block persisting after regression of infectious myocarditis

1 reference

12 December 2020

Cx43 contributes to TGF-beta signaling to regulate differentiation of cardiac fibroblasts into myofibroblasts

1 reference

12 December 2020

Connexin40 nonsense mutation in familial atrial fibrillation

1 reference

12 December 2020

Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury

1 reference

12 December 2020

Ischemia induces closure of gap junctional channels and opening of hemichannels in heart-derived cells and tissue

1 reference

12 December 2020

Knock-down of endothelial connexins impairs angiogenesis

1 reference

12 December 2020

Connexin43 silencing in myofibroblasts prevents arrhythmias in myocardial cultures: role of maximal diastolic potential

1 reference

12 December 2020

Gap junctional communication controls the overall endothelial calcium response to vasoactive agonists

1 reference

12 December 2020

Connexins in atherosclerosis

1 reference

12 December 2020

Endothelial Cx40 limits myocardial ischaemia/reperfusion injury in mice

1 reference

12 December 2020

Titration of the gap junction protein Connexin43 reduces atherogenesis

1 reference

12 December 2020

Cellular Communications in the Heart

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS19030866

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29543751%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29543751%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference