Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway (Q74562743)

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11 November 2019

title

Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway (English)

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11 November 2019

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C Y Yan

1

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11 November 2019

L A Greene

series ordinal

2

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11 November 2019

publication date

1 June 1998

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11 November 2019

published in

Journal of Neuroscience

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11 November 2019

volume

18

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11 November 2019

page(s)

4042-4049

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11 November 2019

issue

11

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Treatment of four siblings with progressive myoclonus epilepsy of the Unverricht-Lundborg type with N-acetylcysteine

11 November 2019

cites work

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12 December 2020

Antioxidants as well as oxidants activate c-fos via Ras-dependent activation of extracellular-signal-regulated kinase 2 and Elk-1

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12 December 2020

Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species.

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12 December 2020

Glutathione deficiency is associated with impaired survival in HIV disease

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12 December 2020

Nerve growth factor employs multiple pathways to induce primary response genes in PC12 cells

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12 December 2020

NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells

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12 December 2020

Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons

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12 December 2020

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

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12 December 2020

Active p21Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons

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12 December 2020

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

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12 December 2020

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

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12 December 2020

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

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12 December 2020

A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction

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12 December 2020

Evidence for N-acetylcysteine-sensitive nitric oxide storage as dinitrosyl-iron complexes in lipopolysaccharide-treated rat aorta

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12 December 2020

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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12 December 2020

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

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12 December 2020

Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMP

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12 December 2020

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

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12 December 2020

Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase

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12 December 2020

Chemoprevention of colorectal tumors: role of lactulose and of other agents.

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12 December 2020

The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid

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12 December 2020

Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support

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12 December 2020

Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade.

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12 December 2020

Redox regulation of fos and jun DNA-binding activity in vitro

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12 December 2020

Regulation of neuronal survival by the serine-threonine protein kinase Akt

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12 December 2020

Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.

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12 December 2020

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

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12 December 2020

Inhibition of p42 and p44 mitogen-activated protein kinase activity by PD98059 does not suppress nerve growth factor-induced survival of sympathetic neurones

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12 December 2020

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

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12 December 2020

Survival in patients with amyotrophic lateral sclerosis, treated with an array of antioxidants.

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12 December 2020

Reduction of lower motor neuron degeneration in wobbler mice by N-acetyl-L-cysteine

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12 December 2020

Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells

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12 December 2020

Mechanisms and Functions of Cell Death

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12 December 2020

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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12 December 2020

Phosphatidylinositol-3-OH kinase as a direct target of Ras

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12 December 2020

Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death

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12 December 2020

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

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12 December 2020

Activation of protein kinase cascades by osmotic shock

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12 December 2020

Guanosine 5'-(gamma-thio)triphosphate binding assay for solubilized G proteins.

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12 December 2020

Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: effects of Ca(2+)-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death

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12 December 2020

N -Acetylcysteine Enhances Hippocampal Neuronal Survival After Transient Forebrain Ischemia in Rats

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12 December 2020

Activation of p44 and p42 MAP kinases is not essential for the survival of rat sympathetic neurons

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12 December 2020

N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro

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12 December 2020

The role of estrogens on the proliferation of human breast tumor cells (MCF-7).

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12 December 2020

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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12 December 2020

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity

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12 December 2020

Effects of cellular aging on the induction of c-fos by antioxidant treatments

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12 December 2020

N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells

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12 December 2020

Receptor protein-tyrosine kinases and their signal transduction pathways

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12 December 2020

Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses

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12 December 2020

Antioxidant and redox regulation of gene transcription

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12 December 2020

N-acetylcysteine-promoted survival of PC12 cells is glutathione-independent but transcription-dependent

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12 December 2020

N-acetylcysteine: pharmacological considerations and experimental and clinical applications.

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12 December 2020

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

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12 December 2020

The activation of phosphatidylinositol 3-kinase by Ras

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12 December 2020

NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk

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12 December 2020

Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor

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12 December 2020

Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons

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12 December 2020

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

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12 December 2020

The redox active components H2O2 and N-acetyl-L-cysteine regulate expression of c-jun and c-fos in lens systems

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12 December 2020

10.1523/JNEUROSCI.18-11-04042.1998

Identifiers

DOI

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11 November 2019

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11 November 2019

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